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ANDRES DAVID KLEIN POSTERNACK

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

Líneas de Investigación


Design of novel strategies for uncovering modifier genes/pathways of biological processes in health and disease based on natural genetic variations of yeast, fly, mouse and humans combined with other omics approaches. Systems Genetics.

Educación

  •  Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
  •  Life Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

  •   Postdoc Full Time

    WEIZMANN INSTITUTE OF SCIENCE

    Rehovot, Israel

    2011 - 2015

  •   Postdoc Full Time

    STANFORD UNIVERSITY

    Stanford, Estados Unidos

    2009 - 2011

  •   Group Leader Full Time

    Universidad del Desarrollo-Clínica Alemana

    SANTIAGO, Chile

    2017 - A la fecha

  •   Staff Scientist Full Time

    Telethon Institute of Genetics and Medicine

    POZZUOLI, Italia

    2015 - 2017

Experiencia Profesional

  •   Staff Scientist Full Time

    Telethon Institute of Genetics and Medicine

    POZZUOLI, Italia

    2015 - 2017

Formación de Capital Humano


He dirigido a 3 tesistas de pregrado y actualmente dirigo a 2 tesistas de doctorado


Difusión y Transferencia


Selection of congress presentations:

-- Klein A, Cancino GI, Amigo J, Lazo O, Bronfman F, Alvarez AR and Zanlungo S; Papel de la vía c-Abl/p73 en neurodegeneración en la enfermedad de Niemann-Pick tipo C (NPC); poster; 2006; CHILE; Annual Meeting of the Chilean Cell Biology Society (Best doctorate panel)
- Klein AD, Lopez ME, Scott MP; poster; 2011 USA; Temporal and spatial rescue of the lysosomal storage disorder Niemann-Pick C; Gordon Research Conference on LSDs. Selected to give a short oral talk.
- Klein AD, Vitner EB, Farfel-Becker T, Zigdon H, Futerman AH; oral 2012; GERMANY; Pathology of Neuronal Forms of Gaucher Disease; B4B Meeting.
- Klein AD, Futerman AH; poster; 2013 ITALY; Identifying novel genes that modify the severity of Gaucher disease; Gordon Research Conference in LSDs. Selected to give a short oral talk.

Invited talks

- Klein AD; 2013; CHILE. Gaucher disease: from cell dysfunction to phenotypic variability. First Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2014; TURKEY. Pathological mechanisms in neuronal forms of Gaucher disease: FEBS Advanced Lecture Course: 360° Degree Lysosome.
- Klein AD; 2014; BRAZIL. Gaucher disease: from early neuronal alterations to phenotypic variability. Second Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2015: USA. "Genome wide association studies in mouse models of Gaucher disease unraveled novel potential modifier genes of disease progression". Gordon Research Seminar.
- Klein AD 2016; Germany. Identification of modifier genes in lysosomal storage disorders. MPS2016 meeting.
- Klein AD 2016; UK. Moving forwards towards precision medicine in lysosomal disorders. UCL, invited by Prof. John Hardy.

Scientific Advisory Boaard:
2017-2020: Scientific Advisory Board member at Cures Within Reach.
http://www.cureswithinreach.org/about-us/boards/science-advisory-board


Premios y Distinciones

  •   Innovadores menores de 35 años

    MIT technology reviews

    Chile, 2013

    For design and implement a mouse genetics strategy for uncovering modifier genes of gaucher disease progression

  •   100 líderes jóvenes chienos del 2013

    Revista del sábado, diario "El Mercurio"

    Chile, 2013

    For design and implement a mouse genetics strategy for uncovering modifier genes of Gaucher disease progression

  •   Scientific Advisory Board

    Cures Within Reach

    Estados Unidos, 2017

    Science Advisory and Grant Review Board

  •   Pew Latin American Fellow in the Biomedical Sciences

    Pew Charitable Trust

    Chile, 2009

    Postdoctoral Fellowship

  •   Postdoctoral Fellowship

    UK Gaucher Association

    Reino Unido, 2013

    Postdoctoral Fellowship

  •   Postdoctoral Fellowship

    Ara Parseghian Medical Research Foundation

    Estados Unidos, 2009

    Postdoctoral research fellowship for Niemann-Pick type C studies


 

Article (36)

c-Abl activates RIPK3 signaling in Gaucher disease

Yañez, M.J.; Campos, F.; Marín, T.; Klein, A.D.; Futerman, A.H.; Alvarez, A.R.; Zanlungo, S.

Article
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease  (2021)

Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer A.; Klein, Andres D.; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony H.; Addo, Marylyn M.; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp A.; Lang, Karl S.

Article ISI
FRONTIERS IN IMMUNOLOGY  (2021)

Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein–Deficient Mice

Meneses-Salas, Elsa; Garcia-Forn, Marta; Castany-Pladevall, Carla; Lu, Albert; Fajardo, Alba; Jose, Jaimy; Wahba, Mohamed; Bosch, Marta; Pol, Albert; Tebar, Francesc; Klein, Andrés D.; Zanlungo, Silvana; Pérez-Navarro, Esther; Grewal, Thomas; Enrich, Carlos; Rentero, Carles

Article
The American Journal of Pathology  (2021)

c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

Contreras, Pablo S.; Tapia, Pablo J.; Gonzalez-Hodar, Lila; Peluso, Ivana; Soldati, Chiara; Napolitano, Gennaro; Matarese, Maria; Heras, Macarena Las; Valls, Cristian; Martinez, Alexis; Balboa, Elisa; Castro, Juan; Leal, Nancy; Platt, Frances M.; Sobota, Andrzej; Winter, Dominic; Klein, Andres D.; Medina, Diego L.; Ballabio, Andrea; Alvarez, Alejandra R.; Zanlungo, Silvana

Article ISI
ISCIENCE  (2020)

Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage

Klein A.D.; González de la Vega J.; Zanlungo S.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

Finding pathogenic commonalities between Niemann-Pick type C and other lysosomal storage disorders: Opportunities for shared therapeutic interventions

Yanez, M. J.; Marin, T.; Balboa, E.; Klein, A. D.; Alvarez, A. R.; Zanlungo, S.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

NPC1 as a Modulator of Disease Severity and Viral Entry of Sars-CoV-2

; Vial, Cecilia; Calderón, Juan Francisco; Klein, Andrés D.

Article
Current Molecular Medicine  (2020)

Role of proteases in dysfunctional placental vascular remodelling in preeclampsia

Gutierrez, Jaime A.; Gomez, Isabel; Chiarello, Delia, I; Salsoso, Rocio; Klein, Andres D.; Guzman-Gutierrez, Enrique; Toledo, Fernando; Sobrevia, Luis

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

Modeling Parkinson's Disease Heterogeneity to Accelerate Precision Medicine

Olivares, Gonzalo H.; Olguin, Patricio; Klein, Andres D.

Article ISI SCOPUS
TRENDS IN MOLECULAR MEDICINE  (2019)

Rare diseases in Chile: challenges and recommendations in universal health coverage context

Encina, Gonzalo; Castillo-Laborde, Carla.; Lecaros, Juan A.; Dubois-Camacho, Karen; Calderon, Juan F.; Aguilera, Ximena; Klein, Andres D.; Repetto, Gabriela M.

Article ISI SCOPUS
ORPHANET JOURNAL OF RARE DISEASES  (2019)

Gadolinium chloride rescues Niemann–Pick type C liver damage

Klein A.D.; Oyarzún J.E.; Cortez C.; Zanlungo S.

Article ISI SCOPUS
international journal of mole  (2018)

Is Parkinsons disease a lysosomal disorder?

Klein, AD; Mazzulli, JR

Article ISI SCOPUS
BRAIN  (2018)

Modeling diseases in multiple mouse strains for precision medicine studies

Klein, Andres D.

Article ISI
PHYSIOLOGICAL GENOMICS  (2017)

Modeling diseases in multiple mouse strains for precision medicine studies.

Klein, Andrés D

Article
Physiological genomics  (2017)

Brain Disorders Due to Lysosomal Dysfunction

Fraldi, Alessandro; Klein, Andres D.; Medina, Diego L.; Settembre, Carmine; Hyman, SE

Article ISI
ANNUAL REVIEW OF NEUROSCIENCE, VOL 39  (2016)

Brain Disorders Due to Lysosomal Dysfunction.

Fraldi, Alessandro; Klein, Andrés D; Medina, Diego L; Settembre, Carmine

Article
Annual review of neuroscience  (2016)

Delineating pathological pathways in a chemically induced mouse model of Gaucher disease

Vardi, Ayelet; Zigdon, Hila; Meshcheriakova, Anna; Klein, Andres D.; Yaacobi, Chen; Eilam, Raya; Kenwood, Brandon M.; Rahim, Ahad A.; Massaro, Giulia; Merrill, Alfred H., Jr.; Vitner, Einat B.; Futerman, Anthony H.

Article ISI
JOURNAL OF PATHOLOGY  (2016)

Identification of Modifier Genes in a Mouse Model of Gaucher Disease

Klein, Andres D.; Ferreira, Natalia-Santos; Ben-Dor, Shifra; Duan, Jingjing; Hardy, John; Cox, Timothy M.; Merrill, Alfred H., Jr.; Futerman, Anthony H.

Article ISI
CELL REPORTS  (2016)

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy

Mosbech, Mai-Britt; Olsen, Anne S. B.; Neess, Ditte; Ben-David, Oshrit; Klitten, Laura L.; Larsen, Jan; Sabers, Anne; Vissing, John; Nielsen, J?rgen E.; Hasholt, Lis; Klein, Andres D.; Tsoory, Michael M.; Hjalgrim, Helle; Tommerup, Niels; Futerman, Anthony H.; M?ller, Rikke S.; Faergeman, Nils J.

Article
Annals of Clinical and Translational Neurology  (2014)

RIPK3 as a potential therapeutic target for Gaucher's disease

Vitner, Einat B; Salomon, Ran; Farfel-Becker, Tamar; Meshcheriakova, Anna; Ali, Mohammad; Klein, Andr?s D; Platt, Frances M; Cox, Timothy M; Futerman, Anthony H

Article
NATURE MEDICINE  (2014)

The unique case of the Niemann-Pick type C cholesterol storage disorder

Klein A.D.; Alvarez A.; Zanlungo S.

Article SCOPUS
Pedriatric Endocrinology Reviews  (2014)

Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice

Sáez PJ; Orellana, JA; Vega-Riveros, N; Figueroa, VA; Hernández DE; Castro, JF; Klein, AD; Jiang JX; Zanlungo S.; Sáez JC

Article ISI SCOPUS
PLOS ONE  (2013)

Lysosomal storage disorders: old diseases, present and future challenges

Klein, AD; FUTERMAN, AH

Article Medline
Pedriatric Endocrinology Reviews  (2013)

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

Cabeza, C; Figueroa, A; Lazo O.M.; Galleguillos, C; Pissani C.; Klein, A.; Gonzalez-Billault, C; Inestrosa, N. C.; Alvarez, A.R.; Zanlungo S.; Bronfman F.C.

Article ISI SCOPUS
Molecular Neurodegeneration  (2012)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C

Lopez, Manuel E.; Klein, Andres D.; Scott, Matthew P.

Article ISI
JOURNAL OF NEUROINFLAMMATION  (2012)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C.

Lopez, Manuel E; Klein, Andres D; Scott, Matthew P

Article
Journal of neuroinflammation  (2012)

Lysosomal vitamin E accumulation in Niemann-Pick type C disease

Yevenes L.F., Klein A; Castro J.F., Marín T; Leal N., Leighton; F, Alvarez A.R.

Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2012)

Lysosomal vitamin E accumulation in Niemann-Pick type C disease

Yevenes L.F.; Klein, A.; Castro, J.F.; Marín T; Leal, N; Leighton F.; Alvarez, A.R.; Zanlungo S.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2012)

Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C

Lopez, Manuel E.; Klein, Andrés D.; Hong, Jennifer; Dimbil, Ubah J.; Scott, Matthew P.

Article
Human Molecular Genetics  (2012)

Anatomically Defined Neuron-Based Rescue of Neurodegenerative Niemann-Pick Type C Disorder

Lopez, Manuel E.; Klein, Andres D.; Dimbil, Ubah J.; Scott, Matthew P.

Article ISI
JOURNAL OF NEUROSCIENCE  (2011)

Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease

Klein, A.; Mosqueira, M; Martinez, G; Robledo, F; Gonzalez, M.; Caballero, B; Cancino, GI; Alvarez, AR; hetz C.; Zanlungo S.

Article ISI SCOPUS
NEURODEGENERATIVE DISEASES  (2011)

Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology

Parra J.; Klein, AD; Castro J.; Morales, MG; Mosqueira, M; Valencia I.; Cortés V.; Rigotti, A.; Zanlungo S.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2011)

Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons

Klein, A.; Maldonado, C; Vargas LM; Gonzalez, M.; Robledo, F; de Arce KP; Muñoz FJ.; hetz C.; Alvarez, AR; Zanlungo S.

Article ISI SCOPUS
NEUROBIOLOGY OF DISEASE  (2011)

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease

Alvarez, AR; Klein, A.; Castro J.; Cancino, GI; Amigo, J; Mosqueira, M; Vargas LM; Yevenes, LF; Bronfman, FC; Zanlungo S.

Article ISI SCOPUS
FASEB JOURNAL  (2008)

Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse

Tichauer, JE; Morales, MG; Amigo, L; Galdames L.; Klein, A.; Quiñones V.; Ferrada C.; Alvarez A.; Rio, MC; Miquel, JF; Rigotti, A.; Zanlungo S.

Article ISI SCOPUS
WORLD JOURNAL OF GASTROENTEROLOGY  (2007)

NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis

Klein, A.; Amigo, L; Retamal, MJ; Morales, MG; Miquel, JF; Rigotti, A.; Zanlungo S.

Article ISI SCOPUS
HEPATOLOGY  (2006)

Letter (1)

Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease

Calderon JF; Klein, AD

Letter ISI SCOPUS
MOLECULAR GENETICS AND METABOLISM REPORTS  (2018)

Proyecto (8)

Uncovering the genetic basis of phenotypic heterogeneity in Parkinson disease

Klein, Andrés D.; Olguín, Patricio

Proyecto
 (2019)

UNCOVERING MODIFIER GENES OF LYSOSOMAL BIOLOGY BY EXPLOITING THE NATURAL GENETIC VARIATION OF INBRED MOUSE STRAINS

Klein, Andrés D.

Proyecto
 (2018)

LysoMod

European Union, Horizon 2020 Program, Research and Innovation Staff Exchange (RISE) (734825)

Proyecto
2017-2021
Coinvestigador(a)

Unraveling the role of cellular clearance in GM2 gangiosidosis

Cure and Action for Tay-Sachs (CATS) Foundation, UK (NA)

Proyecto
2016-2018
Inv. Principal

Unraveling the role of cellular clearance in GM2 gangiosidosis

Klein, AD; Medina DL

Proyecto
 (2016)

Identification of novel genes that modify the severity of Gaucher disease

Rosetree of Trust, UK (NA)

Proyecto
2014-2016
Inv. Principal

Identification of novel genes that modify the severity of Gaucher disease

Klein, AD; FUTERMAN, AH; HARDY, J

Proyecto
 (2014)

LysoMod

Carmo-Fonseca, M; Klein, AD; Zanlungo S.; FUTERMAN, AH; Platt FM; John Spencer; Stefana Petrescu; Alberto Kornblihtt; Anabella Srebrow; Beverly Davidson

Proyecto This consortium include researches from the following institutions: -Clinica Alemana-Universidad del Desarrollo -Pontificia Universidad Catolica de Chile -Weizmann Institute of Science -University of Oxford -University of Sussex -Institute of Biochemistry, Academia Romana -Universidad de Buenos Aires -University of Pennsylvania -Universidade de Lisboa
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38
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

19
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

7
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

5
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

2
ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

2
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

2
Gonzalo Cancino

Assistant Professor

Faculty of Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Juan Calderon

Investigador

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

2
Carla Castillo

Assistant Professor

Centro de Epidemiología y Políticas de Salud / Center of Epidemiology and Health Policy

Universidad del Desarrollo

Santiago, Chile

1
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Patricio Olguín

Assistant Professor

Facultad de Medicina, ICBM, Departamento de Neurociencia

Universidad de Chile

Santiago, Chile

1
Claudia Pissani

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

1
Tamara Marín

PhD en Ciencias médicas

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Lecaros

Associate professor

Observatory of Bioethics and Law

Universidad del Desarrollo

Santiago, Chile

1
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Julio Amigo

Assistant Professor

Physiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

1
PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

1
Carolina Cabeza

Académica y Jefa de Centro de Investigación

Universidad Bernardo O'Higgins

Santiago , Chile

1
Maria Yañez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

1
Macarena Las Heras

Estudiante PhD

Universidad del Desarrollo

Santiago, Chile

1
Alexis Martinez

Investigador postdoctoral senior

Facultad de medicina

Instituto de Neurcoeincia Biomedica

Santiago, Chile