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Leyla Morelia Alegria Vargas

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Epidemiología, Sueño en paciente crítico, sindrome post UCI

Epidemiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
Enfermera Matrona, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Enfermera de Investigación Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2012 - 2023
Profesor Asistente Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago , Chile

2023 - A la fecha
Profesor Asistente Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago , Chile

2023 - A la fecha

Enfermera Clínica Unidad de Cuidados Intensivos Full Time

Hospital Clínico de la Universidad Católica de Chile

Chile

2005 - 2012
Comité Editorial Other

Revista Chilena de Medicina Intensiva

Chile

2015 - A la fecha
Comité Cientifico Part Time

Sociedad Chilena de Medicina Intensiva

Santiago, Chile

2017 - A la fecha

Tutora de tesis de Magíster de Epidemiología, Facultad de Medicina, Pontificia Universidad Católica de Chile
Co-Tutora de tesis de Magíster en Psicología de la Salud, Escuela de Psicología, Pontificia Universidad Católica de Chile


Customized normothermic machine perfusion decreases ischemia-reperfusion injury compared with static cold storage in a porcine model of liver transplantation Riveros, Sergio; Marino, Carlo; Ochoa, Gabriela; Soto, Dagoberto; Alegria, Leyla; Jose Zenteno, Maria; San Martin, Sebastian; Branes, Alejandro; Achurra, Pablo; Rebolledo, Rolando Article ISI ARTIFICIAL ORGANS (2023)
Improve sleep in critically ill patients: Study protocol for a randomized controlled trial for a multi-component intervention of environment control in the ICU Alegria, Leyla; Brockmann, Pablo; Repetto, Paula; Leonard, Douglas; Cadiz, Rodrigo; Paredes, Fabio; Rojas, Idalid; Moya, Ana; Oviedo, Vanessa; Garcia, Patricio; Bakker, Jan Article ISI PLOS ONE (2023)
Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile Cornejo, Rodrigo A.; Montoya, Jorge; Gajardo, Abraham I. J.; Graf, Jeronimo; Alegria, Leyla; Baghetti, Romyna; Irarrazaval, Anita; Santis, Cesar; Pavez, Nicolas; Leighton, Sofia; Tomicic, Vinko; Morales, Daniel; Ruiz, Carolina; Navarrete, Pablo; Vargas, Patricio; Galvez, Roberto; Espinosa, Victoria; Lazo, Marioli; Perez-Araos, Rodrigo A.; Garay, Osvaldo; Sepulveda, Patrick; Martinez, Edgardo; Bruhn, Alejandro; SOCHIMI Prone-COVID-19 Grp Article ISI ANNALS OF INTENSIVE CARE (2022)
Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study Contreras, Roberto; Hernandez, Glenn; Daniel Valenzuela, Emilio; Gonzalez, Cecilia; Ulloa, Rodrigo; Soto, Dagoberto; Castro, Ricardo; Guzman, Camila; Oviedo, Vanessa; Alegria, Leyla; Vidal, Diego; Morales, Sebastian; Adolfo Ospina-Tascon, Gustavo; Bakker, Jan; Kattan, Eduardo Article ISI JOURNAL OF CLINICAL MONITORING AND COMPUTING (2022)
Reduction of Respiratory Rate in COVID-19-Associated ARDS Felipe Damiani, L.; Oviedo, Vanessa; Alegria, Leyla; Soto, Dagoberto.; Basoalto, Roque; Consuelo Bachmann, M.; Jalil, Yorschua; Santis, Cesar; Vera, Magdalena; Retamal, Jaime.; Bruhn, Alejandro.; Bugedo, Guillermo. Article ISI RESPIRATORY CARE (2022)
Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation Araos, Joaquin; Alegria, Leyla; Garcia, Aline; Cruces, Pablo.; Soto, Dagoberto.; Erranz, Benjamin; Salomon, Tatiana; Medina, Tania; Garcia, Patricio; Dubo, Sebastian; Bachmann, Maria C.; Basoalto, Roque; Valenzuela, Emilio D.; Rovegno, Maximiliano; Vera, Magdalena; Retamal, Jaime.; Cornejo, Rodrigo; Bugedo, Guillermo.; Bruhn, Alejandro. Article ISI BRITISH JOURNAL OF ANAESTHESIA (2021)
Implementation and design of customized ex vivo machine perfusion. Analysis of its first results Riveros, Sergio; Marino, Carlo; Ochoa, Gabriela; Morales, Emilio; Soto, Dagoberto.; Alegria, Leyla; Josefina Zenteno, Maria; Branes, Alejandro; Achurra, Pablo; Rebolledo, Rolando A. Article ISI ARTIFICIAL ORGANS (2021)
Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial Castro, Ricardo; Kattan, Eduardo; Ferri, Giorgio; Pairumani, Ronald; Daniel Valenzuela, Emilio; Alegria, Leyla; Oviedo, Vanessa; Pavez, Nicolas; Soto, Dagoberto; Vera, Magdalena; Santis, Cesar; Astudillo, Brusela; Cid, Maria Alicia; Bravo, Sebastian; Ospina-Tascon, Gustavo; Bakker, Jan; Hernandez, Glenn Article ISI ANNALS OF INTENSIVE CARE (2020)
Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications Pavez, Nicolas; Kattan, Eduardo; Vera, Magdalena; Ferri, Giorgio; Daniel Valenzuela, Emilio; Alegria, Leyla; Bravo, Sebastian; Pairumani, Ronald; Santis, Cesar; Oviedo, Vanessa; Soto, Dagoberto.; Ospina-Tascon, Gustavo; Bakker, Jan; Hernandez, Glenn; Castro, Ricardo Article ISI ANNALS OF TRANSLATIONAL MEDICINE (2020)
Low Spontaneous Breathing Effort during Extracorporeal Membrane Oxygenation in a Porcine Model of Severe Acute Respiratory Distress Syndrome Dubo, Sebastian; Oviedo, Vanesa; Garcia, Alinee; Alegria, Leyla; Garcia, Patricio; Valenzuela, Emilio Daniel; Damiani, L. Felipe; Araos, Joaquin; Medina, Tania; Bachmann, Maria Consuelo; Basoalto, Roque; Bravo, Sebastian; Soto, Dagoberto.; Cruces, Pablo.; Guzman, Pablo; Retamal, Jaime.; Cornejo, Rodrigo; Bugedo, Guillermo.; Brebi, Priscilla; Bruhn, Alejandro. Article ISI ANESTHESIOLOGY (2020)
Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial Kattan E.; Ospina-TascÃ³n G.A.; Teboul J.-L.; Castro R.; Cecconi M.; Ferri G.; Bakker J.; HernÃ¡ndez G.; Hernandez G.; Ospina-TascÃ³n G.; Damiani L.P.; Estenssoro E.; Dubin A.; Hurtado J.; Friedman G.; Castro R.; AlegrÃa L.; Teboul J.-L.; Cecconi M.; Ferri G.; Jibaja M.; Pairumani R.; FernÃ¡ndez P.; Barahona D.; Cavalcanti A.B.; Bakker J.; Hernandez G.; AlegrÃa L.; Ferri G.; Rodriguez N.; Holger P.; Soto N.; Pozo M.; Bakker J.; Cook D.; Vincent J.-L.; Kavanagh B.P.; Dellinger P.; Rietdijk W. Article ISI SCOPUS CRITICAL CARE (2020)
Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure? Dubo, Sebastián; Valenzuela, Emilio Daniel; Aquevedo, Andrés; Jibaja, Manuel; Berrutti, Dolores; Labra, Christian; Lagos, Rossana; García, María Fernanda; Ramírez, Vanessa; Tobar, Milton; Picoita, Fabricio; Peláez, Cristian; Carpio, David; Alegría, Leyla; Hidalgo, Carolina; Godoy, Karen; Bruhn, Alejandro.; Hernández, Glenn; Bakker, Jan; Castro, Ricardo; Lionetti, Vincenzo Article ISI SCOPUS PLOS ONE (2019)
Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock=> The ANDROMEDA-SHOCK Randomized Clinical Trial. Hernández, Glenn; Ospina-Tascón, Gustavo A; Damiani, Lucas Petri; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Granda-Luna, Vladimir; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Ospina-Tascón, Gustavo; Petri Damiani, Lucas; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Alegría, Leyla; Ferri, Giorgio; Rodriguez, Nicolás; Holger, Patricia; Soto, Natalia; Pozo, Mario; Bakker, Jan; Cook, Deborah; Vincent, Jean-Louis; Rhodes, Andrew; Kavanagh, Bryan P; Dellinger, Phil; Rietdijk, Wim; Carpio, David; Pavéz, Nicolás; Henriquez, Elizabeth; Bravo, Sebastian Article JAMA (2019)
Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation. Araos, Joaquin; Alegria, Leyla; Garcia, Patricio; Cruces, Pablo; Soto, Dagoberto; Erranz, Benjamín; Amthauer, Macarena; Salomon, Tatiana; Medina, Tania; Rodriguez, Felipe; Ayala, Pedro; Borzone, Gisella R; Meneses, Manuel; Damiani, Felipe; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro Article American journal of respiratory and critical care medicine (2019)
Early goal-directed therapy using a physiological holistic view=> the ANDROMEDA-SHOCK-a randomized controlled trial. Hernández, Glenn; Cavalcanti, Alexandre Biasi; Ospina-Tascón, Gustavo; Zampieri, Fernando Godinho; Dubin, Arnaldo; Hurtado, F Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Cecconi, Maurizio; Teboul, Jean-Louis; Bakker, Jan Article Annals of intensive care (2018)
Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP -Lactamase Biosensor. Andresen, Max; Araos, Joaquin; Wong, Kwok-Yin; Leung, Yun-Chung; So, Lok-Yan; Wong, Wai-Ting; Cabrera, Salvador; Silva, Camila; Alegria, Leyla; Bruhn, Alejandro; Soto, Dagoberto Article Sensors (Basel, Switzerland) (2018)
Statistical analysis plan for early goal-directed therapy using a physiological holistic view - The andromeda-shock: A randomized controlled trial HernÃ¡ndez G.; Cavalcanti A.B.; Ospina-TascÃ³n G.; Dubin A.; Hurtado F.J.; Damiani L.P.; Friedman G.; Castro R.; AlegrÃa L.; Cecconi M.; Teboul J.-L.; Bakker J.; Hernandez G.; Ospina-TascÃ³n G.; Cavalcanti A.B.; Dubin A.; Hurtado F.J.; Friedman G.; Castro R.; AlegrÃa L.; Teboul J.-L.; Cecconi M.; Damiani L.P.; Bakker J. Article ISI SCOPUS Revista Brasileira de Terapia Intensiva (2018)
The practice of intensive care in Latin America: a survey of academic intensivists Castro, R; Nin N.; Rios, F; Alegria, L; Estenssoro, E; Murias, G; Friedman, G; Jibaja, M; Ospina-Tascon, G; Hurtado, J; Marin, MD; Machado, FR; Cavalcanti, AB; Dubin, A; Azevedo, L; Cecconi, M; Bakker, J; Hernandez, G Article ISI SCOPUS CRITICAL CARE (2018)
A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study Alegría Leyla; Hernández Glenn; Bakker, Jan; Teboul Louis; Ospina-Tascón Gustavo Article ISI SCOPUS ANNALS OF INTENSIVE CARE (2017)
Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock. Hernández, Glenn; Tapia, Pablo; Alegría, Leyla; Soto, Dagoberto; Luengo, Cecilia; Gomez, Jussara; Jarufe, Nicolas; Achurra, Pablo; Rebolledo, Rolando; Bruhn, Alejandro; Castro, Ricardo; Kattan, Eduardo; Ospina-Tascón, Gustavo; Bakker, Jan Article Critical care (London, England) (2016)
Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome Araos, J; Alegria, L; Garcia P.; Damiani, F; Tapia, P; Soto, D; Salomon T.; Rodriguez,F; Amthauer M.; Erranz B.; CASTRO, G; Carreño P.; Medina T.; Retamal J.; Cruces P.; Bugedo G.; Bruhn A. Article SCOPUS American Journal of Translational Research (2016)
Method Based on the beta-Lactamase PenPC Fluorescent Labeled for beta-Lactam Antibiotic Quantification in Human Plasma Andresen M.; Wong, KY; Leung, YC; Wong, WT; Chan, PH; Andresen-Vasquez, M; Alegria, L; Silva C.; Tapia, P; Downey P.; Soto, D Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2016)
Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion Tapia, P; Soto, D; Bruhn A.; Alegria, L; Jarufe, N; Luengo C.; Kattan E.; Regueira T.; Meissner, A; Menchaca, R; Vives, MI; Echeverria, N; Ospina-Tascon, G; Bakker, J; Hernández G. Article ISI SCOPUS Critical Care (2015)


Impacto de una estrategia de comunicación precoz e integral en la prevención de síntomas depresivos en pacientes con Covid-19 grave, sus familiares y el personal de salud Alegria, Leyla; Eduardo Tobar A.; Paula Repetto L.; Manuel Ortiz; Verónica Rojas; María Pilar Celis Proyecto ClinicalTrials NCT05035563 (2021)
Capillary refill time response to a rapid fluid challenge in septic shock patients: pathophysiological determinants, and relation to changes in systemic, regional and microcirculatory blood flow. Glenn Hernández P; Leyla Alegria Proyecto (2020)
Impact of the use a multifaceted intervention of environment control in the ICU to optimize quantity and quality of sleep in critically ill patients. Alegria, Leyla Proyecto (2020)
“Secuelas psicológicas en pacientes críticos a los tres meses del alta de la Unidad de Cuidados Intensivos” Pontificia Universidad Católica de Chile (180904004) Proyecto 2019-2020 Tesista
PERIPHERAL PERFUSION VERSUS LACTATE-TARGETED FLUID RESUSCITATION IN SEPTIC SHOCK=> A RANDOMIZED CONTROLLED STUDY FONDECYT (1170043) Proyecto 2017-2020 Coinvestigador(a)