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Paula Camila Sotomayor Fahrenkrog

Investigador

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Investigación de resistencias a drogas anti-cancerígenas. Estudio del microambiente y vasculatura tumoral. Marcadores diagnósticos y pronósticos en cáncer.

Educación

  •  Licenciado en Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2004
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 2005
  •  PhD Ciencias Biológicas, STATE UNIVERSITY OF NEY YORK AT BUFFALO. Estados Unidos, 2013

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD ANDRES BELLO

    Medicina

    Santiago, Chile

    2014 - 2018

  •   Investigador Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad Andrés Bello

    SANTIAGO, Chile

    2014 - 2018

  •   Investigador Full Time

    Pontificia Universidad Católica de Chile

    SANTIAGO, Chile

    2018 - A la fecha


 

Article (25)

Anti-Inflammatory Chilean Endemic Plants

Otero, Carolina; Klagges, Carolina; Morales, Bernardo; Sotomayor, Paula; Escobar, Jorge; Fuentes, Juan A; Moreno, Adrian A; Llancalahuen, Felipe M; Arratia-Perez, Ramiro; Gordillo-Fuenzalida, Felipe; Herrera, Michelle; Martínez, Jose L; Rodríguez-Díaz, Ma

Article
PHARMACEUTICS  (2023)

Active Surveillance in Prostate Cancer: Current and Potentially Emerging Biomarkers for Patient Selection Criteria

Sotomayor, Paula C. C.; Aguilar, Juan C. C.; Mujica, Karen; Zuniga, Alvaro; Godoy, Alejandro S. S.; Smith, Gary J. J.; Mohler, James L. L.; Vitagliano, Gonzalo; San Francisco, Ignacio F. F.

Article ISI
UROLOGIA INTERNATIONALIS  (2022)

The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells

Torres-Estay, Veronica; Mastri, Michalis; Rosario, Spencer; Fuenzalida, Patricia; Echeverria, Carolina E.; Flores, Emilia; Watts, Anica; Cerda-Infante, Javier; Montecinos, Viviana P.; Sotomayor, Paula C.; Amigo, Julio; Escudero, Carlos; Nualart, Francisco; Ebos, John M. L.; Smiraglia, Dominic J.; Godoy, Alejandro S.

Article ISI
CANCERS  (2022)

Dietary Fructose Promotes Prostate Cancer Growth

Carreno, Daniela, V; Corro, Nestor B.; Cerda-Infante, Javier F.; Echeverria, Carolina E.; Asencio-Barria, Catalina A.; Torres-Estay, Veronica A.; Mayorga-Weber, Gonzalo A.; Rojas, Pablo A.; Veliz, Loreto P.; Cisternas, Pedro A.; Montecinos, Viviana P.; San Francisco, Ignacio F.; Varas-Godoy, Manuel A.; Sotomayor, Paula C.; Castro, Maite A.; Nualart, Francisco J.; Inestrosa, Nibaldo C.; Godoy, Alejandro S.

Article ISI
CANCER RESEARCH  (2021)

Intranasal delivery of interferon-beta-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy

Gonzalez, Luis F.; Acuna, Eric; Arellano, Gabriel; Morales, Paola; Sotomayor, Paula; Oyarzun-Ampuero, Felipe; Naves, Rodrigo

Article ISI
JOURNAL OF CONTROLLED RELEASE  (2021)

Fructose and prostate cancer: toward an integrated view of cancer cell metabolism

Carreno, Daniela; Corro, Nestor; Torres-Estay, Veronica; Veliz, Loreto P.; Jaimovich, Rodrigo; Cisternas, Pedro; San Francisco, Ignacio F.; Sotomayor, Paula C.; Tanasova, Marina; Inestrosa, Nibaldo C.; Godoy, Alejandro S.

Article ISI SCOPUS
PROSTATE CANCER AND PROSTATIC DISEASES  (2019)

Androgens modulate male-derived endothelial cell homeostasis using androgen receptor-dependent and receptor-independent mechanisms

Torres-Estay, Verónica; Carreño, Daniela V.; Fuenzalida, Patricia; Watts, Anica; San Francisco, Ignacio F.; Montecinos, Viviana P.; Sotomayor, Paula C.; Ebos, John; Smith, Gary J.; Godoy, Alejandro S.

Article ISI SCOPUS
ANGIOGENESIS  (2017)

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

Pinto, Mauricio; SOTOMAYOR, PAULA; Carrasco-Avino, Gonzalo; Corvalan, Alejandro; Owen, Gareth

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2016)

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

Ramakrishnan, Swathi; Ku, ShengYu; Ciamporcero, Eric; Miles, Kiersten Marie; Attwood, Kris; Chintala, Sreenivasulu; Shen, Li; Ellis, Leigh; SOTOMAYOR, PAULA; Swetzig, Wendy; Huang, Ray; Conroy, Dylan; Orillion, Ashley; Das, Gokul; Pili, Roberto

Article ISI SCOPUS
BMC CANCER  (2016)

Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications

Adelaiye, R.; Ciamporcero, E.; Miles, K. M.; Sotomayor, P.; Bard, J.; Tsompana, M.; Conroy, D.; Shen, L.; Ramakrishnan, S.; Ku, S.-Y.; Orillion, A.; Prey, J.; Fetterly, G.; Buck, M.; Chintala, S.; Bjarnason, G. A.; Pili, R.

Article
Molecular Cancer Therapeutics  (2015)

Dll4 Blockade Potentiates the Anti-Tumor Effects of VEGF Inhibition in Renal Cell Carcinoma Patient-Derived Xenografts

Miles, Kiersten Marie; Seshadri, Mukund; Ciamporcero, Eric; Adelaiye, Remi; Gillard, Bryan; SOTOMAYOR, PAULA; Attwood, Kristopher; Shen, Li; Conroy, Dylan; Kuhnert, Frank; Lalani, Alshad S.; Thurston, Gavin; Pili, Roberto; Kyprianou, Natasha

Article
PLOS ONE  (2014)

Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression

Godoy, A. S.; Sotomayor, P. C.; Villagrán M.; Yacoub R.; Montecinos, V. P.; McNerney E.M.; Moser M.; Foster B.A.; Onate S.A.

Article ISI SCOPUS
Biochemical and Biophysical Research Communications  (2012)

Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue

Reinicke K; Sotomayor P.; Cisterna, P; Delgado C.; Nualart, F.; Godoy A.

Article ISI SCOPUS
Journal of Cellular Biochemistry  (2012)

Characterization of iNOS+ Neutrophil-like ring cell in tumor-bearing mice

Virtuoso, Lauren P; Harden, Jamie L; SOTOMAYOR, PAULA; Sigurdson, Wade J; Yoshimura, Fuminobu; Egilmez, Nejat K; Minev, Boris; Kilinc, Mehmet O

Article
JOURNAL OF TRANSLATIONAL MEDICINE  (2012)

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

Shen, Li; Ciesielski, Michael; Ramakrishnan, Swathi; Miles, Kiersten M.; Ellis, Leigh; SOTOMAYOR, PAULA; Shrikant, Protul; Fenstermaker, Robert; Pili, Roberto; Ling, Ming Tat

Article
PLOS ONE  (2012)

Vascular Disruption in Combination with mTOR Inhibition in Renal Cell Carcinoma

Ellis, L.; Shah, P.; Hammers, H.; Lehet, K.; Sotomayor, P.; Azabdaftari, G.; Seshadri, M.; Pili, R.

Article
Molecular Cancer Therapeutics  (2012)

Androgen deprivation induces rapid involution and recovery of human prostate vasculature

Godoy A.; Montecinos, V. P.; Gray, D. R.; Sotomayor P.; Yau, J. M.; Vethanayagam, R. R.; Singh, S; Mohler, J. L.; Smith, G. J.

Article ISI
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM  (2011)

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Pettazzoni, Piergiorgio; Pizzimenti, Stefania; Toaldo, Cristina; SOTOMAYOR, PAULA; Tagliavacca, Luigina; Liu, Song; Wang, Dan; Minelli, Rosalba; Ellis, Leigh; Atadja, Peter; Ciamporcero, Eric; Dianzani, Mario Umberto; Barrera, Giuseppina; Pili, Roberto

Article
Free Radical Biology and Medicine  (2011)

TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells

Safina, A.; Sotomayor, P.; Limoge, M.; Morrison, C.; Bakin, A. V.

Article
Molecular Cancer Research  (2011)

Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12

Akakura, Shin; Nochajski, Peter; Gao, Lingqiu; SOTOMAYOR, PAULA; Matsui, Sei-ichi; Gelman, Irwin H.

Article
Cell Cycle  (2010)

ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate

Mathew, Grinu; Timm, Earl A.; Sotomayor, Paula; Godoy, Alejandro; Montecinos, Viviana P.; Smith, Gary J.; Huss, Wendy J.

Article
CELL CYCLE  (2009)

Oct4A is expressed by a subpopulation of prostate neuroendocrine cells

SOTOMAYOR, PAULA; Godoy, Alejandro; Smith, Gary J.; Huss, Wendy J.

Article
The Prostate  (2009)

Androgen Receptor Is Causally Involved in the Homeostasis of the Human Prostate Endothelial Cell

Godoy, Alejandro; Watts, Anica; Sotomayor, Paula; Montecinos, Viviana P.; Huss, Wendy J.; Oñate, Sergio A.; Smith, Gary J.

Article
ENDOCRINOLOGY  (2008)

Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2

Godoy A.; Ormazabal, V; Moraga-Cid, G; Zuniga, FA; Sotomayor P.; Barra V; Vásquez O.; Montecinos, V.; Mardones L.; Guzmán C; Villagrán M.; Aguayo, LG; Onate, SA; Reyes, AM; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione

Montecinos, V.; Guzman P.; Barra V; Villagrán M.; Munoz-Montesino, C; Sotomayor, K; Escobar, E; Godoy A.; Mardones L.; Sotomayor P.; Guzmán C; Vásquez O.; Gallardo V.; van Zundert, B; Bono, MR.; Onate, SA; Bustamante, M; Carcamo, JG; Rivas, CI; Vera, JC

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Proyecto (4)

Paracrine Effect of the Endothelium on Prostate Cancer Cells and Its Role During Tumor Progression

FONDECYT (224119)

Proyecto
2016-2018
Coinvestigador(a)

Nano-Carbosome=> Development of a nanoparticle loaded with Carboplatin and Proteasome Inhibitor against resistance and recurrence in ovarian cancer.

Proyectos Núcleos UNAB

Proyecto
2014-2017
Coinvestigador(a)

Role of Pericytes and Tumor Epithelial Cells in the Acquisition of Resistance to Antiangiogenic Therapy

FONDECYT (11140255)

Proyecto
2014-2018
Inv. Principal

Plataforma de estudios preclínicos de xenotransplantes de tejidos metastáticos humanos para la evaluación de sensibilidad a drogas anticancerígenas.

FONDEF (CA12i10333)

Proyecto
2012-2015
Investigador(a)

Review (3)

Biological role of fructose in the male reproductive system: Potential implications for prostate cancer

Echeverria, Carolina E.; Oyarzun, Vanessa I.; Lopez-Cortes, Andres; Cancino, Jorge; Sotomayor, Paula C.; Goncalves, Marcus D.; Godoy, Alejandro S.

Review ISI
PROSTATE  (2023)

Exercise and prostate cancer: From basic science to clinical applications

Campos, C; Sotomayor, P; Jerez, D; Gonzalez, J; Schmidt, CB; Schmidt K.; Banzer, W; Godoy, AS

Review ISI SCOPUS
PROSTATE  (2018)

Androgen receptor in human endothelial cells

Torres-Estay, V; Carreno, DV; Francisco, IFS; Sotomayor P.; Godoy, AS; Smith, GJ

Review ISI SCOPUS
Journal of Endocrinology  (2015)

28
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

12
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

8
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

4
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

3
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

2
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

2
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

1
CAROLINA DELGADO

Encargado de proyectos de desarrollo de Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Christian Campos

Decano

Universidad Andrés Bello

santiago, Chile

1
Néstor Corro