Man

Isaac Eduardo Garcia Carrillo

Profesor Adjunto

Universidad de Valparaiso

Valparaiso, Chile

Líneas de Investigación


Ion channel biophysics, Channelopaties, Connexins, Pannexins, inflammation and Nociception, Electrophysiology

Educación

  •  Biological Science, Neuroscience, UNIVERSIDAD DE VALPARAISO. Chile, 2014
  •  Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 2008
  •  Ciencias Naturales y Exactas, UNIVERSIDAD DE CHILE. Chile, 2003

Experiencia Académica

  •   Visiting Researcher Other

    RUTGERS UNIVERSITY NEWARK

    MEDICAL SCIENCE

    Newark, Estados Unidos

    Enero 2014 - Enero 2015

  •   PROFESOR ADJUNTO Full Time

    UNIVERSIDAD DE VALPARAISO

    FACULTAD DE ODONTOLOGIA

    VALPARAISO, Chile

    Enero 2018 - A la fecha

Experiencia Profesional

  •   Visiting Researcher Full Time

    New Jersey Medical School, Rutgers University, Department of Pharmacology and Physiology

    Newark, NJ, Chile

    Enero 2014 - Enero 2015


Tipos de Producción
 

Dtp Import/Article (10)

Charged residues at the first transmembrane region contribute to the voltage dependence of connexins slow gate
Conexinopathies=> a structural and functional glimpse
Extracellular cysteines in connexins=> a role as redox sensors
From hyperactive Connexin26 hemichannels to impairments in epidermal calcium gradient and permeability barrier in the Keratitis-Ichthyosis-Deafness syndrome
Diseases associated with leaky hemichannels
Keratitis-Ichthyosis-Deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43
Characterization of a novel water pocket inside the human Cx26 hemi-channel structure
Role of Connexin Channels in Retinal Light Response in a Diurnal Rodent
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

Article (7)

The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels
Calcium binding and voltage gating in Cx46 hemichannels
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins
Conexinopathies: a structural and functional glimpse
Characterization of a novel water pocket inside the human Cx26 hemichannel structure
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

Grant (4)

ROLE OF CCL5/CCR5 AXIS IN THE AGGRESSIVENESS OF ORAL SQUAMOUS CELL CARCINOMA

Abstract (1)

Altered IP3 receptors, IP3-dependent Ca2+transients and Ca2+-dependent gene expression in a Duchenne muscular dystrophy cell line

Review (1)

Redox-mediated regulation of connexin proteins; focus on nitric oxide

Book Section (1)

Methods to determine the formation of heteromeric hemichannels

Generic (1)

TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE
15
Isaac Garcia

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

3
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Karel Mena

Profesor de Laboratorio

Ciencias Químicas

Universidad Andres Bello

Santiago, Chile

1
HELMUTH SANCHEZ

INVESTIGADOR JOVEN

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

1
Ricardo Hartley

Académico

Universidad Central de Chile

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile