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ISAAC EDUARDO GARCÍA CARRILLO

Profesor Adjunto

Universidad de Valparaiso

Valparaiso, Chile

Líneas de Investigación


Ion channel biophysics, Channelopaties, Connexins, Pannexins, inflammation and Nociception, Electrophysiology

Educación

  •  Biological Science, Neuroscience, UNIVERSIDAD DE VALPARAISO. Chile, 2014
  •  Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 2008
  •  Ciencias Naturales y Exactas, UNIVERSIDAD DE CHILE. Chile, 2003

Experiencia Académica

  •   Visiting Researcher Other

    RUTGERS UNIVERSITY NEWARK

    MEDICAL SCIENCE

    Newark, Estados Unidos

    2014 - 2015

  •   PROFESOR ADJUNTO Full Time

    UNIVERSIDAD DE VALPARAISO

    FACULTAD DE ODONTOLOGIA

    VALPARAISO, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Visiting Researcher Full Time

    New Jersey Medical School, Rutgers University, Department of Pharmacology and Physiology

    Newark, NJ, Chile

    2014 - 2015


 

Article (7)

The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

Capuccino, JMV; Chatterjee, P; Garcia, IE; Botello-Smith, WM; Zhang, H; Harris, AL; Luo Y.; Contreras, JE

Article ISI SCOPUS
JOURNAL OF GENERAL PHYSIOLOGY  (2019)

The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Garcia, Isaac E; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo, I; Contreras, Jorge E.; Perez-Acle, Tomas; Alvarez, Osvaldo; Latorre, Ramon; Martinez, Agustin D.; Gonzalez, Carlos

Article ISI SCOPUS
JOURNAL OF GENERAL PHYSIOLOGY  (2018)

Calcium binding and voltage gating in Cx46 hemichannels

Pinto, BI; Pupo, A; Garcia, IE; Mena-Ulecia, K; Martinez, AD; Latorre, R; Gonzalez, C

Article ISI SCOPUS
SCIENTIFIC REPORTS  (2017)

Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins

Pinto, BI; Garcia, IE; Pupo, A; Retamal, MA; Martinez, AD; Latorre, R; Gonzalez, C

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2016)

Conexinopathies: a structural and functional glimpse

García IE., Prado, P., Pupo A., Jara, O., Rojas, D., Mujica, P., Flores-Muñoz, C., Gonzalez, J., Soto, C., Pinto, B., Retamal, MA., Gonzalez, C., Martínez AD

Article
BMC CELL BIOLOGY  (2016)

Characterization of a novel water pocket inside the human Cx26 hemichannel structure

Araya-Secchi R., Perez-Acle T., Seung-gu Kang, Huynh T., Escalona Y., Garate JA., Martínez AD., García IE., Sáez JC., Zhou R

Article
Biophys. J.  (2014)

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

Jara O., Acuña R., García IE., Maripillán J., Figueroa V., Sáez JC., Araya R., Lagos C., Perez- Acle T., Berthoud V., Beyer E., Martínez AD

Article
Mol Biol Cell  (2012)

Abstract (2)

TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE

Jaimovich E.; Buvinic, S.; Casas M.; Figueroa, R.; Garcia, I

Abstract
JOURNAL OF PHYSIOLOGICAL SCIENCES  (2009)

Altered IP3 receptors, IP3-dependent Ca2+transients and Ca2+-dependent gene expression in a Duchenne muscular dystrophy cell line

Jaimovich E.; Juretic, N; Garcia, I; Hartley, R; LIBERONA, JL; Figueroa, R.; Riveros, N.; Molgó J.; Cárdenas JC

Abstract ISI
FASEB JOURNAL  (2008)

BookSection (1)

Methods to determine the formation of heteromeric hemichannels

Agustín D. Martínez, Oscar Jara, Ricardo Ceriani, Paula Mujica, and Isaac E. García; Sáez, JC

BookSection
 (2016)

Proyecto (4)

ROLE OF CCL5/CCR5 AXIS IN THE AGGRESSIVENESS OF ORAL SQUAMOUS CELL CARCINOMA

Gonzalez-Arriagada, Wilfredo; Garcia, Isaac E

Proyecto
 (2019)

Papel de los hemicanales de conexinas en el crosstalk entre odontoblastos y fibras nerviosas en la respuesta al dolor inducida por agentes cariogenicos

Garcia, Isaac E; Universidad de Valparaiso

Proyecto
 (2018)

ROLE OF CONNEXIN HEMICHANNELS IN THE CROSSTALK BETWEEN ODONTOBLASTS AND DENTAL PRIMARY AFFERENTS IN CARIOGENIC CONDITIONS

Garcia, Isaac E

Proyecto
 (2018)

Molecular determinants of the interaction between the amino termini and the water pocket of Cx26 hemichannels during gating

Garcia, Isaac E

Proyecto
 (2014)

Review (1)

Redox-mediated regulation of connexin proteins; focus on nitric oxide

Garcia, IE; Sanchez, HA; Martinez, AD; Retamal, MA

Review ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES  (2018)

15
ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

3
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Karel Mena

Profesor de Laboratorio

Ciencias Químicas

Universidad Andres Bello

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

1
Ricardo Hartley

Investigador

Instituto de Investigación y Postgrado

Universidad Central de Chile

Santiago, Chile

1
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile