Rquatrini.png_thumb90

Raquel Clara Quatrini Nyqvist

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

Líneas de Investigación


Microbiology of Acidic Biomes; Population and Community Genomics; Ecophysiology of Extremophiles; Mineral Processing Biotechnologies

Educación

  •  Microbiología, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Biology, Universidad Nacional del Comahue. Argentina, 1998

Experiencia Académica

  •   Research Associate Full Time

    Fundación Ciencia & Vida

    -

    Santiago, Chile

    Enero 2007 - A la fecha

  •   Postdoctoral Researcher Full Time

    Fundación Ciencia & Vida

    -

    Santiago, Chile

    Enero 2004 - Enero 2007

Experiencia Profesional

  •   Research Associate Full Time

    Fundación Ciencia & Vida

    Santiago, Chile

    Enero 2004 - A la fecha

  •   Faculty Comitee, PhD programm in Biotechnology, Part Time

    Universidad Andres Bello

    Santiago, Chile

    Enero 2014 - A la fecha

  •   Faculty Comitee, PhD Programm in Molecular Biosciences Part Time

    Universidad Andres Bello

    Santiago, Chile

    Enero 2010 - Enero 2014

  •   Study Group Member Other

    Fondecyt

    Santiago, Chile

    Enero 2011 - Enero 2013

  •   Study Group Director Other

    Fondecyt

    Santiago, Chile

    Enero 2013 - Enero 2014

Formación de Capital Humano


Thesis direction:

- Doctorate Thesis: 2 in progress, 5 completed

* Ana Rosa Moya Beltrán. Caracterización del pangenoma de los Acidithiobacillus: contribución del complemento génico esencial y accesorio a la diversificación y evolución del taxón. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. In progress, Septiembre 2017 –to date.

* Francisco Luciano Issotta Contardo. Estudio eco-evolutivo de comunidades extremófilas inherentes al gradiente ambiental de un sistema hídrico acídico de origen volcánico en el Norte de Patagonia. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. In progress, Septiembre 2017 –to date.

* Paulo Cesar Covarrubias Pizarro. Tipificación y caracterización genómica y morfológica de virus microbianos presentes en econichos de biolixiviación. Doctorado en Biociencias Moleculares, Universidad Andrés Bello. Completed, 2019.

* Rodrigo Andrés Flores Ríos. Caracterización del sistema TRA de Acidithiobacillus ferrooxidans ATCC 23270 y su papel en la transferencia conjugativa del ICEAfe1. Doctorado en Microbiología, Universidad de Santiago de Chile. Completed, 2018.

* Juan Pablo Cárdenas Astudillo. Estudio genómico-comparativo de la respuesta a estrés oxidativo en microorganismos acidófilos: modelos de función, regulación y evolución. Doctorado en Biotecnología, Universidad Andrés Bello. Completed, 2015.

* Mauricio Arenas. Estudio de las propiedades estructurales del regulador transcripcional FUR de Acidithiobacillus ferrooxidans. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2014.

* Lillian Acuña. Caracterización del Sistema de Inmunidad CRISPR/Cas en Acidithiobacillus caldus. Doctorado en Ciencias Biomédicas, Universidad Andrés Bello. Completed, 2013.

- Masters Thesis: 2 in progress, 3 completed

* Stefano Bueno Rossoni. Caracterización del vesículas secretorias de bacterias del género Acidithiobacillus. Magíster en Biotecnología, Universidad Nacional Andrés Bello. In progress, Julio 2018 - to date.

* Cesar Manuel Valenzuela Alegría. Caracterización del plasmidoma de bacterias del género Acidithiobacillus. Magíster en Biotecnología, Universidad Nacional Andrés Bello. In progress, Junio 2018 - to date.

* Victor Andrés Alegría Mera. Papel del regulador transcripcional Saci1223 sobre la expresión de genes asociados a procesos de producción y conversión de energía en la arquea termoacidófila Sulfolobus acidocaldarius durante la formación de biopelículas. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2017.

* Cristian Silva Fernandez. Mecanismos de Inmunidad Adquirida en Acidithiobacilli. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2011.

* Cristopher Andrés Oporto Alarcón. Estudio de métricas para clustering en redes de asociación funcional de proteínas para genomas microbianos. Magíster en Ingeniería Civil Informática, Universidad de Santago de Chile. Completed, 2009.

- Undergraduate Thesis: 2 in progress, 12 completed

* Ivette Natalia Olave Orellana. Estudio de cepas acidófilas mesotermófilas tipo Acidithiobacillus caldus aisladas del sistema geotermal acídico Copahue-Caviahue y su tolerancia a iones cloruro. Ingeniería en Biotecnología, Universidad Mayor. In progress, Junio 2018 to date.

* Fernanda Sazo Pradenas. Análisis de la diversidad genómica a nivel intra-específico
de bacteria acidófila y principal modelo en biominería, Acidithiobacillus ferrooxidans. Ingeniería en Biotecnología, Universidad Tecnológica Metropolitana. In progress, Diciembre 2017-to date.

* Yazna Tapia Cisternas. Estudio de los mecanismos de resistencia a cadmio en el genero Acidithiobacillus y propuesta de diseño de vector plasmidial potencialmente útil en la construcción de biosensores de cadmio aplicables a la minería. Ingeniería Civil en Biotecnología, Universidad San Sebastián. Completed, 2018.

* Rodolfo Alfredo Gomez Salinas. Contribución del complemento génico flexible al fitness biologico y la competitividad de bacterias del linaje 3 del genero Acidithiobacillus. Ingeniería Civil en Biotecnología, Universidad San Sebastián. Completed, 2018.

* María Ignacia von Unger. Estudio de los elementos integrativos conjugativos tipo 2 presentes en distintas cepas de Acidithiobacillus caldus, y su contribución a la formación de biopeliculas, desde una perspectiva transcripcional. Ingeniería en Biotecnología, Universidad Andrés Bello. Completed, 2016.

* María Isabel Yanquepe. Desarrollo de un pipeline integrativo para la identificación de elementos genéticos móviles en genomas microbianos. Ingeniería en Bioinformática, Universidad de Talca. Completed, September 2014.

* Francisco Luciano Issotta Contardo. Benchmarking de los métodos vigentes de asignación taxonómica y ensamblado de secuencias cortas utilizando metagenomas microbianos y virales sintéticos. Ingeniería en Bioinformática, Universidad de Talca. Completed, 2014.

* Ana Rosa Moya Beltrán. Análisis comparativo de metagenomas microbianos de ecosistemas acídicos y exploración del potencial metabólico común y diferencial. Ingeniería en Bioinformática, Universidad de Talca. Completed, 2014.

* Alfredo Hernán Monsalve Bustos. Análisis ecofisiológico del pangenoma de bacterias de biolixiviación del género Sulfobacillus spp. Pregrado en Ingeniería en Biotecnología, Universidad de Santiago de Chile. Completed, 2013.

* Pablo Tapia Salinas. Identificación y caracterización de un profago presente en el genoma de Acidithiobacillus caldus ATCC 51756. Pregrado en Bioquímica, Pontifícia Universidad Católica de Valparaíso. Completed, 2012

* Juan José Haristoy Lagos. Análisis genómico y funcional de plasmidos cripticos presentes en el genoma de Acidithiobacillus caldus ATCC 51756. Pregrado en Bioquímica, Pontifícia Universidad Católica de Chile. Completed, 2012

* David Loyola. Determinación de cambios en el perfil transcripcional de Escherichia coli expuesta a telurito/cefotaxima utilizando microarreglos de DNA. Pregrado en Ingeniería en Bioinformática, Universidad de Talca. October 2011. Co-advisor.

* Pamela Nieto Pacheco. La unión Fur:DNA in vivo y el efecto de su regulación transcripcional en Acidithiobacillus ferrooxidans. Pregrado en Bioquímica, Universidad de Chile. Completed, 2009. Co-advisor.

* Jorge Herrera. Unión de grupo hemo al regulador Fur de Acidithiobacillus ferrooxidans. Pregrado en Bioquímica, Universidad Católica de Chile. Completed, 2007. Co-advisor.

Teaching:

Doctorate Training (Guest lecturer):
- Programable nucleases and genome editing Class, Biotecnologi?a: Aplicaciones y oportunidades de Negocio en Chile y el Mundo Course (BIO 511), PhD. Program in Biotechnology, Universidad Nacional Andrés Bello
- Transcriptomics Class, Bioinformatics and Genome Biology Course (BIO 502) course, PhD. Program in Biotechnology, Universidad Nacional Andrés Bello

Undergraduate Training (Guest lecturer):
- Introduction to transcriptomics Class, Genetic Engineering and Biotechnology Course (BIT 230), Undergraduate Program in Biomedical Sciences, Universidad Nacional Andrés Bello
- Metabolic Reconstruction Class, Biotechnology of enzymes and metabolic pathways Course, Undergraduate Program in Biotechnology, Universidad de Chile


Difusión y Transferencia


2018 July
Participant in the Exploradores: del átomo al cosmos, TV capsules.
Brief interview on the scientific activities of the Microbial Ecophysiology Lab. Produced by Pablo Rosenblatt to be broadcasted by TVN´s Canal 24 Horas during the 2nd semester of 2018.

2018 January
Scientific advisor in the ongoing production of “LocosLab”.
Animated series for school children produced by DinoGorila (www.dinogorila.com) on diverse contingent scientific topics, including the revolutionary genomic edition tool, CRISPR/Cas9.

2016 August
Participant in the Ciencia para Todos, TV capsules.
Brief interview on the scientific activities of the Microbial Ecophysiology Lab. Produced by Pablo Rosenblatt and broadcasted by TVN´s Canal 24 Horas during the 1st semester of 2017. Available at: https://www.youtube.com/watch?v=XfC6LlQTrWo&feature=youtu.be

2014 September
Scientific advisor in the production of Píldoras Científicas “Ursi y Magnogeek, Exploradores de Otro Mundo”, Temporada 2.
Six aimed videos for school-aged children were developed by Fundación Ciencia & Vida and Imago Productions as part of a series about microbial extremophiles and earth sciences.
These videos were sponsored by Explora Conicyt and the Consejo Nacional de Televisión (CNTV) and are publicly available at Novasur.
www.novasur.cl/videos/el-inicio-del-viaje
www.novasur.cl/videos/avalancha
www.novasur.cl/videos/sofocante-aventura
www.novasur.cl/videos/congeladamente-vivos
www.novasur.cl/videos/profusas-profundidades
www.novasur.cl/videos/perdidos-por-accidente
Author: Ulisse-Luz C
Creator: Rosemblat-Bono I
Science advisors: Quatrini R; Herve Allamand F
Funding: EPA20036


Premios y Distinciones

  •   Scholarship for undergraduate training

    Universidad Nacional del Comahue

    Argentina, 1996

    Scholarship for undergraduate training in Biology at the C.R.U.B, Universidad Nacional del Comahue.

  •   Fellowship for postgraduate technical and scientific training

    Science and Technology Fellowship

    Chile, 1998

    Science and Technology Fellowship for postgraduate technical and scientific training at the Instituto Nacional de Parasitología Mario Fatala Chabén (ANLIS). Buenos Aires, Argentina.

  •   Scholarship for postgraduate training

    UNIVERSIDAD DE CHILE

    Chile, 1999

    German Academic Exchange Service (DAAD) scholarship to achieve the University Degree of Doctor in Microbiology. Faculty of Sciences, Universidad de Chile. Santiago, Chile.

  •   Fellowship for technical training

    Sydney Kimmel Cancer Center

    Estados Unidos, 2004

    Antorchas-American Society for Microbiology (ASM) Fellowship for technical training in microarray technology. Sydney Kimmel Cancer Center. San Diego, California.

  •   Best Incorporation Presentation -SoMiCh 2006

    Sociedad Chilena de Microbiología

    Chile, 2006

    Award to the best Incorporation Presentation to become member of the Chilean Microbiology Society. XVIII Congreso Latinoamericano de Microbiología, Pucón, Chile.

  •   Fellowship for technical training

    European Molecular Biology Organization

    Brasil, 2007

    European Molecular Biology Organization (EMBO) Fellowship for technical training in Comparative Genomics. Rio de Janeiro, Brasil.

  •   Best poster award - IBS 2007

    International Biohydrometallurgy Symposium 2007

    Alemania, 2007

    Award to the best poster at the 17th International Biohydrometallurgy Symposium - IBS 2007. Frankfurt, Germany.

  •   Best poster award

    International Biohydrometallurgy Symposium - IBS 2009

    Argentina, 2009

    Award to the best poster at the 18th International Biohydrometallurgy Symposium - IBS 2009. Bariloche, Argentina.

  •   Honorary mention poster award

    International Biohydrometallurgy Symposium - IBS 2011

    China, 2011

    Award poster honorary mention at the 19th International Biohydrometallurgy Simposium - IBS 2011. Changsha, China.


 

Article (56)

Acidithiobacillus ferrooxidans
Domestication of Local Microbial Consortia for Efficient Recovery of Gold Through Top-Down Selection in Airlift Bioreactors
Nucleotide Second Messenger-Based Signaling in Extreme Acidophiles of the Acidithiobacillus Species Complex: Partition Between the Core and Variable Gene Complements
The Type IV Secretion System of ICEAfe1: Formation of a Conjugative Pilus in Acidithiobacillus ferrooxidans
Insights into the biology of acidophilic members of the Acidiferrobacteraceae family derived from comparative genomic analyses
Microbiomes in extremely acidic environments: functionalities and interactions that allow survival and growth of prokaryotes at low pH.
Occurrence, integrity and functionality of AcaML1-like viruses infecting extreme acidophiles of the Acidithiobacillus species complex
16S rRNA and Multilocus Phylogenetic Analysis of the Iron Oxidizing Acidophiles of the Acidiferrobacteraceae Family
A DNA segment encoding the anticodon stem/loop of tRNA determines the specific recombination of integrative-conjugative elements in Acidithiobacillus species
Are there Viruses in Industrial Bioleaching Econiches?
Comparative Genomics Analysis of a New Exiguobacterium Strain from Salar de Huasco Reveals a Repertoire of Stress-Related Genes and Arsenic Resistance
Draft genome sequence of Acidithiobacillus thiooxidans CLST isolated from the acidic hypersaline Gorbea salt flat in northern Chile
Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)
Genetic Basis of Metal Resistance in Acidiphilium sp. DSM 27270 (Yenapatur)
Metagenome-Derived Draft Genome Sequence of Acidithiobacillus ferrooxidans RV1 from an Abandoned Gold Tailing in Neuquén, Argentina
Molecular Systematics of the Genus Acidithiobacillus: Insights into the Phylogenetic Structure and Diversification of the Taxon
Mutantelec: An In Silico Mutation Simulation Platform for Comparative Electrostatic Potential Profiling of Proteins
Type IV Secretion Systems Diversity in the Acidithiobacillus Genus
Aerobic Lineage of the Oxidative Stress Response Protein Rubrerythrin Emerged in an Ancient Microaerobic, (Hyper)Thermophilic Environment
Detection, identification and typing of Acidithiobacillus species and strains: a review
Draft genome sequence of chloride-tolerant Leptospirillum ferriphilum Sp-Cl from industrial bioleaching operations in northern Chile
Genomic and metagenomic challenges and opportunities for bioleaching: a mini-review
AFAL: a web service for profiling amino acids surrounding ligands in proteins
Draft Genome Sequence of the Iron-Oxidizing, Acidophilic, and Halotolerant "Thiobacillus prosperus" Type Strain DSM 5130
Genetic variability of psychrotolerant Acidithiobacillus ferrivorans revealed by (meta)genomic analysis
Multi Locus Sequence Typing scheme for Acidithiobacillus caldus strain evaluation and differentiation
Analysis of gene expression in response to copper stress in Acidithiobacillus ferrooxidans strain D2, isolated from a copper bioleaching operation.
Architecture and Gene Repertoire of the Flexible Genome of the Extreme Acidophile Acidithiobacillus caldus
DNA, Cell Wall and General Oxidative Damage Underlie the Tellurite/Cefotaxime Synergistic Effect in Escherichia coli
Temporal dynamics of genes involved in metabolic pathways of C and N of L. ferriphilum, in the industrial bioleaching process of Escondida mine, Chile.
Comparative genomics of the oxidative stress response in bioleaching microorganisms
Complete Genome Sequence of Temperate Bacteriophage AcaML1 from the Extreme Acidophile Acidithiobacillus caldus ATCC 51756
ICEAfe1, an Actively Excising Genetic Element from the Biomining Bacterium Acidithiobacillus ferrooxidans
Thiol/Disulfide System Plays a Crucial Role in Redox Protection in the Acidophilic Iron-Oxidizing Bacterium Leptospirillum ferriphilum
Draft Genome Sequence of the Extremely Acidophilic Biomining Bacterium Acidithiobacillus thiooxidans ATCC 19377 Provides Insights into the Evolution of the Acidithiobacillus Genus
Comparative genomics begins to unravel the ecophysiology of bioleaching
A 300 kpb genome segment, including a complete set of tRNA genes, is dispensable for Acidithiobacillus ferrooxidans
Comparative genomics begins to unravel the ecophysiology of bioleaching.
Draft Genome Sequence of the Extremely Acidophilic Bacterium Acidithiobacillus caldus ATCC 51756 Reveals Metabolic Versatility in the Genus Acidithiobacillus
Extending the models for iron and sulfur oxidation in the extreme Acidophile Acidithiobacillus ferrooxidans
Predicted CO/CO2 fixation in Ferroplasma spp. via a novel chimaeric pathway.
Regulation of expression of the PetI operon involved in iron oxidation in the biomining bacterium Acidithiobacillus ferrooxidans.
Selection and evaluation of reference genes for improved interrogation of microbial transcriptomes: case study with the extremophile Acidithiobacillus ferrooxidans
Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications.
Iron homeostasis strategies in acidophilic iron oxidizers: Studies in Acidithiobacillus and Leptospirillum
Microbial iron management mechanisms in extremely acidic environments: comparative genomics evidence for diversity and versatility
Bioinformatic prediction and experimental verification of Fur-regulated genes in the extreme acidophile Acidithiobacillus ferrooxidans
Insights into the metabolism and ecophysiology of three acidithiobacilli by comparative genome analysis.
Iron homeostasis strategies in acidophilic iron oxidizers: Comparative genomic analyses
Insights into the iron and sulfur energetic metabolism of Acidithiobacillus ferrooxidans by microarray transcriptome profiling
Microarray and bioinformatic analyses suggest models for carbon metabolism in the autotroph Acidithiobacillus ferrooxidans
Genomic insights into the iron uptake mechanisms of the biomining microorganism Acidithiobacillus ferrooxidans
The ferric iron uptake regulator (Fur) from the extreme acidophile Acidithiobacillus ferrooxidans
Aspects of the predicted physiology of Acidithiobacillus ferrooxidans deduced from an analysis of its partial genome sequence
Variación morfológica y dieta en dos poblaciones de Liolaemus elongatus Koslowsky, 1896 (Iguania: Tropiduridae) del noroeste patagónico

ConferencePoster (46)

A polyphasic and genomic evaluation of Acidithiobacillus thiooxidans strain diversity uncovers cryptic lineages.
Análisis de la microdiversidad de poblaciones de Acidithiobacillus a lo largo de un gradiente natural de acidéz extrema.
Análisis metagenómico de un consorcio arsénico-tolerante dominado por Acidithiobacillus spp. recuperado del Rio Agrio (Neuquén, Argentina).
Benchmarking of taxonomy assignment methods for metagenomic analysis using acidic microbiomes as test case.
Biofilm formation in Acidiferrobacter murciensis SPIII/3 : a bioinformatics and epifluorescence microscopy study.
Caracterización del Pangenoma de los acidithiobacilli: aspectos diferenciales entre sublinajes de bacterias hierro oxidantes.
Estudio de la diversidad de plasmidios del complejo específico Acidithiobacillus.
Re-evaluation of the Acidithiobacillus species complex based on genomic analysis.
Señalización mediante segundos mensajeros nucleotídicos en la clase bacteriana Acidithiobacillia.
The Acidithiobacilli, genomics and evolution of the taxon.
Variabilidad genética del sistema flagelar y sus implicancias en el fenotipo mótil de bacterias biolixiviantes del género Acidithiobacillus.
16S rRNA and multilocus phylogenetic analysis of the iron oxidizing acidophiles of the Acidiferrobacteraceae family.
Emerging insights into the type IV CRISPR/Cas systems from genomic analyses in the Acidithiobacillus species complex.
Genetic basis of metal resistance in Acidiphilium sp. DSM 27270 (Yenapatur).
Genome analysis of species of the new bioleaching acidophilic bacterial genus Acidiferrobacter.
Mapping Acidithiobacillus populations with high resolution onto a natural environmental gradient.
Metagenome-derived draft genome sequence of Acidithiobacillus ferrooxidans RV1 from an abandoned gold tailing in Neuquén,
Molecular systematics of the genus Acidithiobacillus: insights into the phylogenetic structure and diversification of the taxon.
Phylogenomic-based species delimitation within the genus Acidithiobacillus.
Transcriptomic analysis by RNA-Seq in a TDP-43 aggregation model.
Type IV secretion systems diversity in the Acidithiobacillus genus.
Type IV secretion systems in Integrative Conjugative Elements of the genus Acidithiobacillus.
¿Are there viruses in industrial bioleaching econiches?.
Functional evaluation of proteins involved in metabolism and transduction of c-di-GMP coded in the integrative conjugative element ICEAcaTY.2 of Acidithiobacillus caldus.
Genetic traits associated with distribution of prophages in acidophilic genomes.
Microdiversity of Acidithiobacillus populations recovered from an abandoned tailing in the gold mining district of Andacóllo (Neuquén, Argentina).
Temporal profiling of the microbial community from the lime-treated abandoned mine tailing “Relave Viejo” in Neuquén, Argentina.
C-di-GMP control modules confined within mobile elements: the case of ICEAcaTY.2.
Comparative Analyses of Metagenomes from Acid Mine Drainages.
Genomic taxonomy of the Acidithiobacilli.
Targeted metagenomic analysis of Mynydd Parys Acid Mine Drainage microbial communities.
The Integrative and Conjugative Element ICEAcaTY.2 and its contribution to adhesion and biofilm development.
A Next Generation Multilocus Sequence Typing Scheme for Acidithiobacillus species.
Análisis comparativo de los sistemas CRISPR-Cas presentes en Elementos Conjugativos Integrativos tipo 2 en bacterias del género Acidithiobacillus.
Benchmarking available methods for prediction of Mobile Genetic Elements in complete genomes.
Benchmarking of binning methods using a conceptual metagenome.
Bioinformatic analysis of the incidence of lysogeny in acidophilic genomes and metagenomes.
c-di-GMP pathway modules in the flexible genome of the Acidithiobacilli.
Caracterización del T4SS presente en el ICEAfe1, un elemento genético móvil de la bacteria acidófila Acidithiobacillus ferrooxidans.
Characterization of a T4SS from ICEAfe1, a mobile genetic element from the acidophilic bacterium Acidithiobacillus ferrooxidans.
Comparative analysis of metagenomes from Extremely acidic environments using a phylogenetic approach.
Comprehensive Characterization of the Pangenome of Acidithiobacillus caldus.
Functional analysis of the recombination module from ICEAfe1, a mobile genetic element from the acidophilic bacterium Acidithiobacillus ferrooxidans.
Multi Locus Sequence Typing-based characterization of the intraspecific variability of sulfur oxidizing Acidithiobacilli.
Possible mechanisms of salt stress response in the halotolerant bacterial strain Exiguobacterium sp. SH31 isolated from Salar de Huasco.
The c-di-GMP signal transduction network of bacterial acidophiles.

Proyecto (20)

Análisis de las poblaciones microbianas del botadero San Francisco de la mina Los Bronces e implementación de un programa de monitoreo.
Análisis de poblaciones microbianas en ripios y soluciones industriales de biolixiviación.
Detección de virus microbianos en soluciones industriales de biolixiviación.
Aislamiento y caracterización de microorganismos hierro-azufre oxidantes desde operaciones mineras para el diseño y preparación de consorcios biolixiviantes.
Desarrollo y validación de una estrategia de etiquetado genómico para el monitoreo especie-específico de poblaciones microbianas de biolixiviación.
The role of the core and flexible genomes of Acidithiobacillus species in differentiation and niche adaptation.
Comparative genomic, metagenomic and bioinformatic approaches to generating fundamental and applied knowledge for bioleaching and other acidic econiches.
Molecular biodiversity studies of heap bioleaching systems using high resolution Multi Locus Sequence Typing.
Role of regulatory RNAs in the response of acidophilic, bioleaching microorganisms to environmental challenges.
Virus population dynamics and acquired virus resistance in bioleaching microbial communities.
Whole Genome Sequencing, annotation and metabolic reconstruction of Sulfobacillus thermosulfidooxidans CBAR13.
Development of dedicated DNA arrays for screening of industrial transcriptomes.
Genomic and Bioinformatic Approaches to Discover and Apply Biological Knowledge to Improve Copper Bioleaching.
Comparative genomic modeling of the metabolism of microbial biomining consortia.
Iron homeostasis strategies in acidophilic iron oxidizers: comparative genomic analyses and experimental validations in Acidithiobacillus ferrooxidans.
Global protein-DNA binding site analysis in Acidithiobacillus ferrooxidans: a microarray based genomic mapping of protein binding sites for the iron responsive transcriptional regulator Fur.
El Tatio geysers field as a model system to study virus-host interactions and local adaptations.
International Cooperation: Comparative genomic modeling of the metabolism of microbial biomining consortia.
Millennium  Nucleus in  the  Biology  of  Intestinal  Microbiota
Understanding genomic diversity of the Acidithiobacillus complex in the context of evolutionary ecology.

BookSection (4)

Acidophile Microbiology in Space and Time.
Progress in Acidophile Genomics.
The Flexible Genome of Acidophilic Prokaryotes.
The Use of Bioinformatics and Genome Biology to Advance Our Understanding of Bioleaching Microorganisms

Review (1)

Lessons from the genomes of extremely acidophilic bacteria and archaea with special emphasis on bioleaching microorganisms

BookWhole (1)

Acidophiles: Life in Extremely Acidic Environments.
128
Raquel Quatrini

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

25
David Holmes

Director

Center for Bioinformatics and Genome Biology

FUNDACION CIENCIA PARA LA VIDA Y UNIVERSIDAD ANDRES BELLO (UNAB)

Santiago, Chile

14
Juan Cardenas

Assistant Professor

Universidad Mayor de Chile

Santiago, Chile

11
Jorge Valdes

DIRECTOR

CENTRO DE GENOMICA Y BIOINFORMATICA

UNIVERSIDAD MAYOR

Santiago, Chile

4
Harold Nuñez

PostDoc

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

4
Claudia Lefimil

Profesor Asistente

Instituto de Investigación en Ciencias odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Lillian Acuña

INVESTIGADOR POST-DOCTORAL

LABORATORIO DE ECOFISIOLOGÍA MICROBIANA

FUNDACIÓN CIENCIA & VIDA

SANTIAGO, Chile

3
Inti Pedroso

Profesor Asistente

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

3
Hector Osorio

Postdoctorado

Departamento Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Gloria Levicán

Académica Profesora Asociada

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Mauricio Arenas

Profesor Asistente

Bioinformática

UNIVERSIDAD DE TALCA

talca, Chile

1
Mauricio Acosta

Investigador

Universidad Católica del Norte

Antofagasta, Chile

1
Francisco Remonsellez

Professor

Ingenieria Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Cecilia Demergasso

Directora

Vicerrectoría de Investigación y Desarrollo Tecnológico

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

1
Sabrina Marin

Investigadora

Centro de Biotecnología

Universidad Católica del Norte

Antofagasta, Chile

1
Eduardo Castro

Assistant Professor

Center for Bioinformatics and Integrative Biology

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Roberto Molina

Postdoctoral scholar

Molecular Biology and Microbiology

TUFTS University

Boston, Estados Unidos

1
Claudia Muñoz

Investigador

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

1
Sebastian Valenzuela

Director de Area Veterinaria

Area Veterinaria

Fundación Ciencia para la Vida

Santiago, Chile

1
Mario Vera

Profesor Asistente

Instituto de Ingeniería Biológica y Medica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Renato Chávez

Associate Professor

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Marlén Barreto

Profesor asociado

UNIVERSIDAD AUTONOMA DE CHILE

Santiago de Chile, Chile

1
Susan Bueno

Profesor asociado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile