Man

Mauricio Fernando Budini

Assistant Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Proteinopathies; Molecular and Celular Mechanism of Neurodegeneration processes; Splicing and RNA Biology; Chaperone Mediated Autophagy

Educación

  •  Biólogo Molecular, UNIVERSIDAD NACIONAL DE SAN LUIS. Argentina, 2003
  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Faculta de Odontología

    Independencia, Santiago., Chile

    Enero 2014 - A la fecha

Experiencia Profesional

  •   Research Collaborator Part Time

    Facultad de Medicina. Laboratorio de Biología Molecular de la Transcripción de Señales

    Santiago, Chile

    Enero 2003 - Enero 2004

  •   PhD in Biomedical Sciences Full Time

    Facultad de Medicina. Universidad de Chile

    Santiago, Chile

    Enero 2004 - Enero 2008

  •   Postdoctoral Position Full Time

    International Centre for Genetic Engineering and Biotechnology (ICGEB)

    Trieste, Italia

    Enero 2008 - Enero 2014

  •   Assistant Professor Full Time

    Facultad de Odontología. Universidad de Chile

    Santiago, Chile

    Enero 2014 - A la fecha

Formación de Capital Humano


2009-2014: Postdoctoral position at Molecular Pathology Laboratory. International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Co-direction of undergraduate thesis:

Name: Anna Daria
Tittle: “Sviluppo e Caratterizazzione di un Modello di Aggregazione di TDP-43” (Development and characterization of a TDP-43 aggregation model)
Finished

Name: Giulila Toniutti
Tittle: “Caratterizzazione molecolare dei meccanismi di aggregazione di TDP-43 ed implicazioni nelle malattie neurodegenerative” (Molecular characterization of TDP-43 aggregation mechanisms and its impact in neurodegenerative diseases).
Finished

Co-direction of PhD thesis:

Name: Valentina Romano "Doctor Philosophiae” (PhD) degree in the life sciences". PhD. Open University Program
Finished
Name: Zainuddin Quadri "Doctor Philosophiae” (PhD) degree in the life sciences". PhD. Open University Program
Finished

2014-up-to date:
Name: Sheila Vivanco
Undergraduate Thesis: Dentist. Dentistry Faculty, University of Chile
Co-direcction
Finished: 2016

Name: Francisca Lavin
Undergraduate Thesis: Dentist. Dentistry Faculty, University of Chile
Co-direcction
Finished: 2016

Name: Cecilia Hernando
Undergraduate Thesis: Biochemistry. Pharmaceutical and Chemical Sciences Faculty, University of Chile
Co-direcction
Finished 2016

Name: Sebastián Pino
Undergraduate Thesis: Biotechnology. Sciences Faculty, University of Chile
Co-direcction
On couse

Name: José Moreno
Undergraduate Thesis: Biochemistry. Pharmaceutical and Chemical Sciences Faculty, University of Chile
Director
On course

Name: Felipe Riquelme
Magister Thesis: Biotechnology, Andrés Bello University
Director
On course

Name: Karina Cordero
Magister Thesis: Biotechnology, Andrés Bello University
Director
On course


Difusión y Transferencia


Congress and Meetings assistance

Invited Speaker at the Dipartimento di Scienze Farmacologiche e Biomolecolari Universita' degli Studi di Milano. “Crosstalk between TDP-43 and Chaperone Mediated Autophagy (CMA): what do we know?”. Monday, 18 June 2018. Host: Angelo Poletti

Invited Speaker at the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste. “Crosstalk between TDP-43 and Chaperone Mediated
Autophagy (CMA): what do we know?”. Tuesday, 26 June 2018. Host: Emanuele Buratti

Invited Speaker at the Buenos Aires Research Conference on Autophagy 2017 “Molecular Mechanism in Biology and Diseases”. School of Pharmacy and Biochemistry, University of Buenos Aires. October 23-25, 2017.

XL ANNUAL MEETING CHILEAN BIOCHEMISTRY AND MOLECULAR BIOLOGY SOCIETY (2017). TDP-43 aggregation affects Chaperone Mediated Autophagy (CMA) pathway. Moreno J, Ormeño F, Riquelme F, Corvalan D, Budini M

XL ANNUAL MEETING CHILEAN BIOCHEMISTRY AND MOLECULAR BIOLOGY SOCIETY (2017). Transcriptomic analysis by RNA-Seq in a cellular model of aggregation of TDP-43 protein. Cordero K, Moya-Beltrán A, Ormeño F, Riquelme F, Covarrubias P, Quatrini R, Budini M

XXX ANNUAL MEETING CHILEAN SOCIETY FOR CELL BIOLOGY (2016). Haptoglobin, EIF4e and Annexin-A4 induce a mature phenotype and migration capacity in human dendritic cells: A potential new role as damage associated molecular patterns (DAMPs). Vivanco S., Lavín F., Reyes-Farias M., Budini M., Salazar-Onfray F., González F.E.

XXX ANNUAL MEETING CHILEAN SOCIETY FOR CELL BIOLOGY (2016). Relationship between TDP-43 aggregates and CMA. Riquelme F., Moreno J., Ormeño F., Pino S., Budini M.

XXXVIII ANNUAL MEETING OF BIOCHEMISTRY AND MOLECULAR BIOLOGY OF CHILE (2015). TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain. Budini, M., Romano V., Quadri, Z., Buratti, E., Baralle, EF.

4°AriSLA Convention. Milan (2013). TDP-43-ALTERED METABOLISM IN ALS. Mauricio Budini, Jeremias Herzog, Valentina Romano, Amit Bhardwaj, Zainuddin Quadri, Natasa Skoko, Laura De Conti, Cristiana Stuani, Maurizio Romano, Marco Baralle, Claudia Colombita, Elisa Onesto, Emanuele Buratti, Antonia Ratti and Francisco E. Baralle.

International Sypmposium in “Gene Expression and RNA Processing”. IGUAZU FALLS, MISIONES ARGENTINA, (2011). “Establishing a cellular model of TDP-43 protein aggregation”. Budini, M. F.; Stuani, C.; Guarnaccia, C.; Romano, V.; Buratti, E.; Baralle, F. E.

ICGEB Trieste, Annual Symposium – ICGEB (2011), Trieste, Italy. “TDP-43: determinants of aggregation” Budini, M.

International Symposium on Alternative Splicing in Neurodegenerative Diseases and Cancer. Tel Aviv (2010). “Characterization of peptide sequences that can modulate TDP-43 splicing properties and/or aggregation/localization in neuronal tissues” Budini M., Romano M., Stuani S., Baralle F.E., and Buratti E.

ICGEB Trieste, Annual Symposium – ICGEB (2009), Trieste, Italy. “Targeting the TDP-43/hnRNP Functional Interaction” Budini, M.

XLIX Annual Meeting of Chilean Biology Society. XXIX Annual Meeting of Chilean Biology and Molecular Biology Society. XVIII Annual Meeting of Chilean Botanic Society. XXXVIII Annual Meeting of Chilean Genetic Society (2006). “Caracterization of autophosphorylation of CK1a variants”. Budini, M., Jacob G., Whitesel, M., Allende, C. C., Allende, J. E.

X PABMB Congress. SAIB, XLI Annual Meeting, SAN, XX Annual Meeting (2005). “In vivo phosphorylation of Rotavirus`NSP5 protein by casein kinase 1 a (CK1a)”. Budini, Mauricio F.; Campagna, Michela; Burrone, Oscar and Allende, Jorge E.

XXVI ANNUAL MEETING OF BIOCHEMISTRY AND MOLECULAR BIOLOGY OF CHILE (2003). “Phosphorylation of insert L of the CK1aL (from Zebra Fish) by protein kinase dependent of cAMP, PKA”. Budini, M., Jacob, G., Burzio, V. Allende, C. C., Allende, J. E.

Congress and Meeting Organization

Workshop-Autophagy: Physiological and Pathological Roles. University of Chile. 23rd and 24th November 2016, Santiago, Chile.


Premios y Distinciones

  •   Beca

    International Centre for Genetic Engineering (ICGEB), Triste, Italy.

    Italia, 2009

    Fellowship to develop Postdoctoral position at the Molecular Pathology Laboratory of Dr. Fransisco Baralle.

  •   Beca Nacional

    MECESUP

    Chile, 2004

    Fellowship to develop PhD studies at the Biomedical Sciences Program form Medicine Faculty, University of Chile

  •   Beca Nacional

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2006

    Fellowship to support operational cost of PhD research.

  •   Beca Nacional

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2007

    Fellowship to support the last year of PhD program

  •   Beca de Estadía

    International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

    Italia, 2005

    Short term fellowship to study part of my PhD program at the ICGEB

  •   Beca Nacional

    MINISTERIO DE EDUCACION - ARGENTINA

    Argentina, 1999

    Fellowship to support University Studies at the National University of San Luis, Argentina


 

Article (11)

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
Hyperosmotic stress stimulates autophagy via polycystin-2
NEW ROLES OF THE PRIMARY CILIUM IN AUTOPHAGY
Poly(GP) proteins: a potential pharmacodynamic marker in ALS and FTD
TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain
Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region
Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation
Regulation of Gene Expression by TDP-43 and FUS/TLS in Frontotemporal Lobar Degeneration
TDP-43 Autoregulation: Implications for Disease
Autophosphorylation of Carboxy-Terminal Residues Inhibits the Activity of Protein Kinase CK1 alpha
Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted of casein kinase 1 alpha is associated with the formation of viroplasms with altered morphology and a moderate decrease in virus replication

Proyecto (3)

Mechanisms of Autophagy in Obesity
Regulation of TDP-43 aggregation through Chaperone Mediated Autophagy pathway (CMA): implications in neurodegenerative diseases like ALS
Identification of factors involved or affected in TDP-43 aggregation

Patent (1)

A CELLULAR MODEL FOR THE SCREENING OF MOLECULES AFFECTING TDP-43 AGGREGATION

Review (1)

Targeting TDP-43 in neurodegenerative diseases

Article (1)

Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye.
16
Mauricio Budini

Assistant Professor

Facultad de Odonotología

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

2
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile