Man

Rodrigo Andre Del Rio Troncoso

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Neural control of cardiorespiratory function in heart failure. Carotid chemoreceptors. Autonomic function during intermittent hypoxia mimicking sleep apnea syndrome.

Educación

  •  Licenciado en Ciencias Biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
  •  Magister en Ciencias Biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Doctor en Ciencias Biológicas mención Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011

Experiencia Académica

  •   Profesor Asistente Jornada Completa

    Clínica Alemana-Universidad del Desarrollo.

    Santiago, Chile

    Noviembre 2013 - Abril 2014

  •   Profesor Asistente Full Time

    Universidad Autónoma de Chile

    Ciencias de la Salud

    Santiago, Chile

    Enero 2014 - Enero 2017

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    Enero 2017 - A la fecha

  •   Research Assistant Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    Enero 2011 - Enero 2011

  •   Graduate Teaching Assistant Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    Enero 2010 - Enero 2010

Experiencia Profesional

  •   Consultant Part Time

    SOVA Pharmeceuticals

    Estados Unidos

    Enero 2011 - Enero 2012

  •   Consultant Part Time

    CORIDEA Inc.

    Chile

    Enero 2012 - Enero 2013

Formación de Capital Humano


Undergraduate
2003-11 Teaching activities in General Physiology, Cellular Physiology and Experimental Physiology for Biology, Biochemistry and Medical Students at the P. Universidad Católica de Chile.
2008-11 Laboratory Course of General Physiology for Medical Students at the Universidad del Desarrollo.
2013 Teaching activities in Systems Physiology for Health Sciences Students at Universidad del Desarrollo.
2014-17 Teaching activities in Physiology for Medical Students at Universidad Autonoma de Chile.

Graduate
2014 Lectures in Neurophysiology for the M.Sc. program in Neurociences at the Universidad Autonoma de Chile.
2014 Lectures in Biomedicine Topics for the Ph.D. program in Biomedical Sciences at the Universidad Autonoma de Chile.

Tutoring
2014 Laboratory Research Unit, David Andrade (Ph.D (c)) enrolled in the Ph.D. program in Physiology at the P. Universidad Católica de Chile.
2015 Research Rotation, Camilo Toledo enrolled in the Ph.D. program in Biomedical Sciences at the Universidad Autónoma de Chile.
2016 Research Rotation, Claudia Lucero enrolled in the Ph.D. program in Biomedical Sciences at the Universidad Autónoma de Chile.
2016 Research Rotation, Hugo Diaz enrolled in the Ph.D. program in Biomedical Sciences at the Universidad Autónoma de Chile.

Thesis
2016 Valentin Aliaga, M.Sc Thesis, Program in Neurosciences at the Universidad Autónoma de Chile.
2016 Alexis Arce, M.Sc Thesis, Program in Exercise Sciences at the Universidad Finis Terrae.
2018 Claudia Melipilan, M.Sc. Thesis, Program in Neurosciences at the Universidad Autónoma de Chile.
2018 David Andrade, Ph.D. Thesis, Program in Physiology, at the P. Universidad Católica de Chile.
2018 Camilo Toledo, Ph.D. Thesis, Program in Biomedical Sciences, at the Universidad Autónoma de Chile.

Post-doctoral training
2019-present Dr. Camilo Toledo. Neurocognitive dysfunction in heart failure with preserved ejection fraction.


Difusión y Transferencia


1. Free communications:
1.1. International Scientific Meetings:
- Díaz HS, Andrade DC, Toledo C, Lucero C, Arce-Álvarez A, Del Rio R. Selective ablation of central pre-sympathetic of C1 neurons from of the Rostral Ventrolateral Medulla prevents cardiac function impairment in heart failure rats with preserved ejection fraction. International Society of Autonomic Neuroscience. Nagoya, Japan, 2017.
- Andrade DC, Toledo C, Takakura AC, Moreira TS, Lucero C, Díaz HS, Arce-Álvarez A, Iturriaga R, Del Rio R. Selective ablation of brainstem pre-sympathetic neurons abolishes the progressive decline in cardiac function in HFpEF. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Toledo C, Andrade DC, Díaz HS, Arce-Álvarez A, Lucero C, Del Rio R. Purinergic signaling in the retrotrapezoid nucleus: a new mechanism involved in the development of breathing pattern irregularities in HFpEF rats. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Díaz HS, Andrade DC, Toledo C, Lucero C, Arce-Álvarez A, Del Rio R. Episodic stimulation of the central chemoreflex elicits ventilatory long-term facilitation and respiratory disorders in heart failure rats with preserved ejection fraction: Role of the Retrotrapezoid nucleus. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Lucero C, Andrade DC, Toledo C, Díaz HS, Arce-Álvarez A, Retamal M, Del Rio R. Chronic blockade of Connexin43 Hemichannels reduces Cardiac Arrhythmogenesis in Heart Failure with preserved Ejection Fraction. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Arce-Alvarez A, Andrade DC, Toledo C, Lucero C, Díaz H, Del Rio R. Role of Central Chemoreflex Exercise training is an effective non-pharmacological strategy for restore cardiac autonomic imbalance and cardiac function in heart failure with preserved ejection fraction rats. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Andrade DC, Arce-Alvarez A, Toledo C, Diaz H, Lucero C, Faundez M, Iturriaga R, Del Rio R. Exercise training intolerance in heart failure with preserved ejection fraction is associated with altered chemoreflex gain and sympathoexcitation in rats. Experimental Biology 2017, Chicago USA. FASEB Journal.
- Toledo C, Andrade DC, Lucero C, Diaz H, Arce A, Del Rio R. Decreased purinergic signaling in the RTN is associated with respiratory disorders in HFpEF rats. Experimental Biology 2017, Chicago USA. FASEB Journal
- Del Rio R, Diaz H, Toledo C, Andrade DC, Arce-Alvarez A, Lucero C. Endoplasmic Reticulum Stress and Neuroinflammation in the RVLM: A Novel Mechanism Related to Sympathoexcitation in Preserved Ejection Fraction Heart Failure. Experimental Biology 2017, Chicago USA. FASEB Journal
- Del Rio R, Andrade DC, Lucero C, Arias P, Iturriaga R. Carotid body ablation abrogates hypertension induced by intermittent hypoxia mimicking sleep apnoea. American Physiological Society - The Physiological Society joint Meeting. Dublin, 2016.
- Toledo C, Andrade DC, Lucero C, Arce A, Madrid C, Marcus NJ, Del Rio R. Role of Central Chemoreflex Activation on Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction. American Physiological Society - The Physiological Society joint Meeting. Dublin, 2016.
- Andrade DC, Schultz HD, Marcus NJ, Toledo C, Lucero C, Del Rio R. Enhanced Carotid Body-mediated Chemoreflex Drive in Heart Failure: a Matter of Flow. Experimental Biology 2016, San Diego USA. FASEB Journal
- Del Rio R, Toledo C, Andrade DC, Lucero C, Aliaga V, Marcus NJ, Madrid C. Diastolic Dysfunction and Arrhythmia Incidence are Exacerbated by Central Chemoreflex Activation in HFpEF. Experimental Biology 2016, San Diego USA. FASEB Journal
- Del Rio R, Marcus NJ, Andrade DC, Schultz HD. Carotid body ablation in heart failure: A new pathway for rescuing autonomic balance. International Society in Autonomic Neuroscience, Stresa, Italy, 2015.
- Iturriaga, R., Andrade DC, & Del Rio, R. The carotid body: A new target for rescuing cardiorespiratory and autonomic imbalance induced by intermittent hypoxia mimicking obstructive sleep apnea. International Society in Autonomic Neuroscience, Stresa, Italy, 2015.
- Iturriaga, R., Andrade DC, & Del Rio, R. Carotid Body Ablation Reverses the Hypertension and Autonomic Changes Induced by Intermittent Hypoxia. Experimental Biology 2015, Boston USA. Publicado en FASEB Journal.
- Iturriaga, R., Moya, E., Andrade DC, & Del Rio, R. Crucial role of the carotid body chemoreceptors on the development of high arterial blood pressure during chronic intermittent hypoxia. ISAC Meeting 2014. Leeds, UK.
- Del Rio R, Marcus NJ, Schultz HD. Calorie restriction as a new approach for resetting carotid body chemoreflex control in heart failure. Experimental Biology Meeting 2014. San Diego, CA, USA.
- Del Rio R, Moya EA, Iturriaga R. Selective contribution of inflammation and oxidative stress to the cardiorespiratory and carotid body alterations following intermittent hypoxia. Experimental Biology Meeting 2013. Boston, MA, USA.
- Del Rio R, Marcus NJ, Schultz HD. Carotid body ablation improves survival, breathing disorders and autonomic control in heart failure rats. Experimental Biology Meeting 2013. Boston, MA, USA.
- Del Rio R, Marcus NJ, Stein G, Schultz HD. Hydrogen sulfide contributes to the enhanced chemoreflex ventilatory response to acute hypoxia in heart failure rats. Experimental Biology Meeting 2012. San Diego, CA, USA. FASEB Journal.
- Del Rio R, Moya, Ea, Iturriaga R. Contribution of oxidative stress and inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia. XVIIIth International Symposium of Arterial Chemoreceptors. Hamilton, Canada. 2011.

1.2. National Scientific Meetings:
- Andrade DC, Arce-Álvarez A, Toledo C, Díaz HS, Lucero C, Del Rio R. Role of exercise training on cardiac autonomic control in preserved ejection fraction heart failure. VII Congreso Internacional de Ciencias del Deporte”. 2017, Santiago, Chile.
- Andrade DC, Toledo C, Arce-Álvarez A, Díaz HS, Lucero C, Del Rio R. Exercise training and sympathetic activation in heart failure with preserved ejection fraction: observations in an experimental model. 1st Symposium in Cardiovascular and Respiratory Regulation: A Multidisciplinary Perspective. 2017, Santiago, Chile.
- Andrade DC, Toledo C, Lucero C, Díaz H, Arce-Alvarez A, Del Rio R (Oral Presentation). Selective RVLM C1 neuron ablation improves cardiac sympathetic control in heart failure rats. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Toledo C, Andrade DC, Díaz H, Arce-Alvarez A, Lucero C, Del Rio R. P2X7 receptor signaling in the retrotrapezoid nucleus contribute to breathing pattern irregularities in heart failure. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Díaz HS, Toledo C, Andrade DC, Arce-Álvarez A, Lucero C, Del Rio R. Endoplasmic reticulum stress and neuroinflammation in heart failure: A novel link to sympathoexcitation. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Arce-Álvarez A, Melipillan C, Andrade DC, Toledo C, Díaz H, Lucero C, Del Rio R. Autonomic nervous system impairment in children with pyramidal syndrome. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Andrade DC, Arce-Alvarez A, Toledo C, Lucero C, Díaz H, Del Rio R. Exercise training and cardiac function deterioration in heart failure with preserved ejection fraction: to tolerate or not to tolerate, that is the question. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Toledo C, Andrade DC, Arce-Alvarez A, Lucero C, Díaz H, Del Rio R. Central sympathetic neuron activation is associated with increased production of O2- radical, expression of AT1R and NF-kB in rats with HFpEF. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Lucero CM, Andrade DC, Toledo C, Manríquez M, Díaz H., Chronic connexin 43 hemichannel blockade reduces cardiac arrhythmogenesis and improves cardiac function in heart failure. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Díaz H, Toledo C, Andrade DC, Arce-Alvarez A, Lucero C, Del Río R. Endoplasmic Reticulum stress in chronic heart failure: a link to sympatho-excitation. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Arce-Álvarez A, Andrade DC, Toledo C, Lucero C, Díaz H, Del Rio R. Effects of exercise training on cardiac function and autonomic balance in rats with HFpEF. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Andrade DC. Del Rio R, Iturriaga R. Carotid body ablation as a new tool against to hypertension induced by chronic intermittent hypoxia. LVIII Reunión Anual de la Sociedad de Biología de Chile. 2015, Puerto Vara, Chile.
- Lucero C, Andrade DC, Toledo C, Oyarce MP, Retamal MA, Del Río R. Novel insights in arrhythmogenesis during diastolic heart failure: role of extracellular matrix remodeling and alterations in the electrical conduction system. LVIII Reunión Anual de la Sociedad de Biología de Chile. 2015, Puerto Vara, Chile.
- Toledo C, Andrade DC, Lucero C, Del Rio R. Distinct role of central and peripheral chemoreflex activation on cardiac function adjustments in HFpEF. LVIII Reunión Anual de la Sociedad de Biología de Chile. 2015, Puerto Vara, Chile.
- Andrade DC. Iturriaga R. and Del Rio R. Contribution of the carotid body to the autonomic and cardiorespiratory imbalance induced by intermittent hypoxia. III Jornada de Verano de Neurociencias para Estudiantes de Postgrado. Pontificia Universidad Católica de Chile. 2015. Santiago, Chile.
- Iturriaga R. Andrade DC, Moya E, Del Rio R. Contribución del cuerpo carotideo a la hipertensión inducida por hipoxia intermitente crónica. LVII Reunión Anual de la Sociedad de Biología de Chile, 2014, Puerto Varas, Chile.

2. Simposia
-“Inflammation and Immune Responses”, Del Rio R, Experimental Biology Meeting 2013. Boston, MA, USA.
- "NCAR Trainee Featured Topic”, Del Rio R, Experimental Biology Meeting 2014. San Diego, CA, USA.
- "Carotid Body Chemoreceptors: Beyond the O2 Frontier”, Del Rio R, Experimental Biology Meeting 2014. San Diego, CA, USA.
- “Chemoreflexes and Autonomic Balance in Sleep Apnea - Human Studies and Clinical Implications”, Del Rio R, 1st Panamerican Meeting of Physiological Sciences 2014, Foz do Iguazu, Brasil.
- "Refreshing Perspectives on the Role of the Chemoreflexes in the Control of Cardiorespiratory Functions: New Pathways and Players”, Del Rio R, Experimental Biology Meeting 2015. Boston, MA, USA.
- "Carotid body ablation in heart failure: a new pathway for rescuing autonomic balance”, Del Rio R, International Society for Autonomic Neuroscience Meeting 2015. Stresa, Italy.
-"Central And Peripheral Chemoreflexes And Its Pivotal Role In Pathophysiology: Finding New Avenues To Restore Cardiorespiratory Function”, Del Rio R, LVIII Reunion Anual de la Sociedad de Biologia de Chile 2015. Puerto Varas, Chile.
- "Respiratory-Sympathetic Coupling in Cardiovascular Dysfunctions”, Del Rio R, Experimental Biology Meeting 2016. San Diego, CA, USA.
- "Actions and Interactions of Baroreflexes, Chemoreflexes and Metaboreflexes in Autonomic Regulation and Heart Disease”, Del Rio R, Experimental Biology Meeting 2016. San Diego, CA, USA.
- "The carotid body chemoreflex and its pivotal role in autonomic dysregulation: finding new avenues to restore the autonomic function”, Del Rio R, Physiology 2016. Dublin, Ireland.
- "Central and peripheral chemoreceptors in health and disease: finding new avenues to normalize the chemoreflex function”, Del Rio R, XXXI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas 2016. Huilo Huilo, Chile.
- “Sympathetic regulation in heart failure: role of RVLM C1 neurons”, Del Rio R, I Symposium on Cardiorespiratory regulation: A multidisciplinary perspective. Santiago, Chile.
- “Oscillatory breathing in preserved ejection fraction heart failure”, Del Rio R, XIII Reunión Anual de la Sociedad Chilena de Neurociencias. Chiloe, Chile.

3. Seminaries
- Targeting the carotid body in heart failure: did we find a magic bullet?. 2016. Sao Paulo, Brasil.
- Central chemoreceptors in the pathogenesis of cardiac diastolic dysfunction and arrhythmogenesis. 2016. Paris, Francia.
- Cardiovascular and respiratory dysfunction in Heart Failure: novel pathways and players. 2017. Santiago, Chile.
- How sympathetic is the respiration in heart failure?. 2017, Sao Paulo, Brasil.
- Retrotrapezoid nucleus: A novel player involved in the development of breathing disorders in heart failure. 2017. Paris, Francia.
- Cardiorespiratory alterations in Preserved Ejection Fraction Heart Failure: new pathways and players. 2017. Washington DC, USA.
- Sympathetic modulation of breathing pattern in high output/preserved ejection fraction heart failure. 2017. Omaha, USA.

4. Lectures and Plenary Lectures
4.1. National
- Insuficiencia Cardiaca de gasto preservado y su relación con hipertension arterial: Que nos puede enseñar el cerebro?. 2017, Santiago, Chile.
- Alteraciones del control cardiovascular en niños con síndrome piramidal: resultados del primer estudio clínico. 2017. Punta Arenas, Chile.

4.2. International
- Autonomic Regulation of Cardiovascular Function in Health and Disease. 2014. Omaha, NE, USA.
- Investigación Pre-Clínica en Biomedicina: Mito o Realidad. 2015. Lima, Perú.
- Quimiorreceptores en Insuficiencia Cardiaca: Un Nuevo Blanco Terapeútico para Disminuir la Progresión de la Enfermedad. 2016. Lima, Perú.


Premios y Distinciones

  •   Travel Award

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2009

    CONICYT fellowship to attend international course in Keystone, USA.

  •   Young Latin American Researcher Award

    Society of High Altitude Medicine and Physiology.

    Peru, 2010

    Best Oral presentation.

  •   Travel Award

    Society for Free Radical Biology and Medicine.

    Estados Unidos, 2010

    Best poster presentation

  •   Award for the Best Poster Presentation

    Free Radical and Antioxidants Chilean Group.

    Chile, 2010

    Best poster presentation award

  •   Best Ph.D. Thesis in Biological Sciences

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2011

    Recognition for the best Ph.D thesis.

  •   Post-doctoral Best Poster Presentation.

    Redox Biology Center

    Estados Unidos, 2013

    Award for the best poster presentation among post-doctoral trainees.

  •   Post-doctoral Fellow and Early Career Award

    The American Physiological Society

    Estados Unidos, 2013

    award for early career investigators based on research quality and novelty.

  •   Post-doctoral Best Poster Presentation

    Nebraska Physiological Society

    Chile, 2013

    Best poster presentation.

  •   International Young Physiologist Travel Award

    The American Physiological Societ

    Chile, 2014

    Fellowship for reseachers attending and presenting oral communications at the APS annual meeting.

  •   Award for Best Ph.D. Thesis

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2014

    Distinción a las mejores tesis doctorales.

  •   Travel Award

    The Physiological Society

    Chile, 2014

    Fellowship for organizing and attending the 1st Panamerican meeting in Physiological Sciences.

  •   Beca para estudios de Doctorado

    CONICYT

    Chile, 2007

    Apoyo económico otorgado a estudiantes de postgrado realizando doctorado nacional

  •   Elsevier Award for Best Oral Presentation in Basic Research

    International Society for Autonomic Neuroscience

    Italia, 2015

    Award for the best oral pressentation in the 2015 congress of the International Society of Autonomic Neurosciences (ISAN), held in Stresa, Italy, from 26th-29th September

  •   Runner-up for the Early Investigator Prize

    The Physiological Society

    Reino Unido, 2014

    This initiative is designed to reward early career authors who publish outstanding research papers in The Journals of the American Physiological Society. It is sponsored by our publishers

  •   International Young Physiologist Travel Award

    American Physiological Society

    Chile, 2016

    The International Early Career Physiologist (IECP) Travel Awards are presented to graduate students, post-doctoral fellows and junior faculty members who work outside the United States. This initiative of the International Physiology Committee is designed to assist with travel expenses that international early career physiologists incur in attending the Experimental Biology Meeting in order to present their work. Up to 12 awards of $1,000 each will be made annually.

  •   Travel Award

    The Physiological Society

    Reino Unido, 2016

    The Journal of Physiology is pleased to offer an Early Investigator Prize. This initiative is designed to reward early career authors who publish outstanding research papers in The Journal. It is sponsored by both The Journal and our publishers Wiley-Blackwell

  •   International Travel Award

    American Physiological Society

    Estados Unidos, 2017

    The International Early Career Physiologist (IECP) Travel Awards are presented to graduate students, post-doctoral fellows and junior faculty members who work outside the United States. This initiative of the International Physiology Committee is designed to assist with travel expenses that international early career physiologists incur in attending the Experimental Biology Meeting in order to present their work. Up to 12 awards of $1,000 each will be made annually.

  •   NCAR New Iinvestigator Award

    American Physiological Society

    Chile, 2018

    The Neural Control and Autonomic Regulation Section (NCAR) New Investigator Award ($1,000 plus reimbursement of the advance registration fee), made possible by APS Strategic Partner, ADInstruments, recognizes an outstanding investigator in the early stages of his/her independent career. Candidates should be investigators who have made meritorious contributions to the area represented by the NCAR Section. They should not be above the rank of Assistant Professor or a comparable position in a research track at an academic institution or in industry (e.g. Scientist, Research Investigator, etc.). Eligible candidates must not have held the rank of Assistant Professor or equivalent for more than 3 years [month/year] from the date of award application deadline. Applicants also must not have held an advanced degree (PhD, MD, DVM or equivalent) for more than 8 years [month/year] from the date of award application deadline. The applicant must be an APS member in good standing with a primary affiliation in the NCAR Section.


Tipos de Producción
 

Article (61)

Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure
Heart rate variability alterations in infants with spontaneous hypertonia
Kinematic And Neuromuscular Measures Of Intensity During Plyometric Jumps
Acute Effects of Systemic Erythropoietin Injections on Carotid Body Chemosensory Activity Following Hypoxic and Hypercapnic Stimulation
Effects of Plyometric Training on Explosive and Endurance Performance at Sea Level and a High Altitude
Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure
Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats
Ventilatory and Autonomic Regulation in Sleep Apnea Syndrome: A Potential Protective Role for Erythropoietin?
Benefits of oxytocin administration in obstructive sleep apnea
Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats
Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure
Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure
Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in Rats
Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease
Chronic phenytoin treatment reduces rat carotid body chemosensory responses to acute hypoxia
Extracellular Cysteine in Connexins: Role as Redox Sensors
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation
Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
Crucial Role of the Carotid Body Chemoreceptors on the Development of High Arterial Blood Pressure During Chronic Intermittent Hypoxia
Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure
In adult female hamsters hypothyroidism stimulates D1 receptor-mediated breathing without altering D1 receptor expression
Inflammation and oxidative stress during intermittent hypoxia: the impact on chemoreception
Lipopolysaccharide-Induced Ionized Hypocalcemia and Acute Kidney Injury in Carotid Chemo/Baro-Denervated Rats
Mechanisms of carotid body chemoreflex dysfunction during heart failure
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis
Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies
Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control
The carotid body and its relevance in pathophysiology
Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure
Carotid body potentiation during chronic intermittent hypoxia: implication for hypertension
Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure
Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression
Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea
Simvastatin Treatment Attenuates Increased Respiratory Variability and Apnea/Hypopnea Index in Rats With Chronic Heart Failure
Carotid Chemoreceptor Ablation Improves Survival in Heart Failure Rescuing Autonomic Control of Cardiorespiratory Function
Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Role of the Carotid Body in the Pathophysiology of Heart Failure
Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia
Role of neurotransmitter gases in the control of the carotid body in heart failure
Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment
Cardiorespiratory Alterations Induced by Intermittent Hypoxia in a Rat Model of Sleep Apnea
Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link
Comparative respiratory strategies of subterranean and fossorial octodontid rodents to cope with hypoxic and hypercapnic atmospheres
Cardioventilatory Acclimatization Induced by Chronic Intermittent Hypoxia
Evidence for Histamine as a New Modulator of Carotid Body Chemoreception
Modulatory effects of histamine on cat carotid body chemoreception
Chronic intermittent hypoxia enhances carotid body chemosensory responses to acute hypoxia
Endothelins in the cat petrosal ganglion and carotid body: Effects and immunolocalization
Role of endothelin-1 on the enhanced carotid body activity induced by chronic intermittent hypoxia
Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
Inhibitory effects of NO on carotid body: contribution of neural and endothelial nitric oxide synthase isoforms

Abstract (16)

Decreased purinergic signaling in the RTN is associated with respiratory disorders in HFpEF rats
Endoplasmic Reticulum Stress and Neuroinflammation in the RVLM: A Novel Mechanism Related to Sympathoexcitation in Preserved Ejection Fraction Heart Failure
Exercise training intolerance in heart failure with preserved ejection fraction is associated with altered chemoreflex gain and sympathoexcitation in rats
Diastolic Dysfunction and Arrhythmia Incidence are Exacerbated by Central Chemoreflex Activation in HFpEF
Enhanced Carotid Body-mediated Chemoreflex Drive in Heart Failure: a Matter of Flow
Carotid Body Ablation Reverses the Hypertension and Autonomic Changes Induced by Intermittent Hypoxia
Reduced Carotid Body KLF2 Expression Contributes to Autonomic and Respiratory Dysfunction in Chronic Heart Failure
Calorie restriction as a new approach for resetting carotid body chemoreflex control in heart failure
Chronic Intermittent Hypoxia Increases 3-nitrotyrosine Formation and Enhances the Hypoxic Chemosensory Response of the Rat Carotid Body
Paradoxical effect of L-NAME on cat carotid body exposed to chronic intermittent hypoxia

Grant (7)

Review (5)

Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus on Metabolism and Membrane Excitability
Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure
Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia
Carotid body potentiation induced by intermittent hypoxia: Implications for cardiorespiratory changes induced by sleep apnoea

Letter (3)

COMMENT ON "PRECEDENCE AND AUTOCRACY IN BREATHING CONTROL"
Comment on "Precedence and autocracy in breathing control" [2]
Reply from Noah J. Marcus, Rodrigo Del Rio and Harold D. Schultz

Conference Paper (3)

Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia
Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia
Rabbit ventilatory responses to peripheral chemoexcitators: Effects of chronic hypoxia

Editorial Material (1)

Editorial: Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease

Nil Class (0)

101
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

51
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

19
Harold Schultz

Full Professor

Cellular & Integrative Physiology

University of Nebraska

Omaha, Estados Unidos

8
Julio Alcayaga

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

7
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

6
David Andrade

Assistant Profesor

Universidad Mayor

Santiago, Chile

4
Mauricio Retamal

Profesor Asociado

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

3
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

2
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

2
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Carlos Madrid

Universidad del Desarrollo (UDD)

Santiago, Chile

2
Juan Orellana

Assistant Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fernando Ezquer

Profesor Asociado

Centro de Medicina Regenerativa

Universidad del Desarrollo

Santiago, Chile

1
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

1
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Marcelo Ezquer

Director/Profesor asociado

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

1
Felipe Court

Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Bernardo Krause

Assistant Professor

Division of Pediatrics

CENTRO DE INVESTIGACIONES MÉDICAS, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Irving Santos

Asesor técnico

Departamento de Enfermedades no Transmisibles (DIPRECE). Departamento GES, Redes Complejas y Líneas Programáticas (DIGERA). Hospital Digital.

Ministerio de Salud

Santiago, Chile

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Claudia Melipillan

Kinesióloga

Corporación de Rehabilitación Club de Leones Cruz del Sur.

Punta Arenas, Chile

1
CRISTIAN ALVAREZ

Profesor Asociado

Ciencias de La Actividad Física

Universidad de Los Lagos

Osorno, Chile