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Julio Cristian Amigo Donoso

Assistant Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

Zebrafish model system angiogenesis hematopoiesis high through put screen platform tissue regeneration

Cellular Molecular Biology, UNIVERSIDAD DE CHILE. Chile, 2005
Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

2014 - A la fecha

Research associate Other

Massachusetts Institute of Technology

Boston, Estados Unidos

2011 - A la fecha
postdoctoral fellow Full Time

Harvard Medical School

Boston, Estados Unidos

2007 - 2014

Teaching HMS-MIT & BWH
Experience Taught and introduce the use of the zebrafish model system for developmental studies to undergraduate and post-doctoral students (2007-present).
Taught molecular biology and confocal microscopy techniques to undergraduate and post-doctoral students (2007-present).
Taught phenotipic and genotipic analysis to undergraduate and post-doctoral students (2007-present).

Conicyt PhD grants

U. Chile

Chile, 1999

National Convention of Science and Technology (CONICYT, Chile) merit scholarships 1999-2002 Award for best Ph.D. candidate Chilean Government (1999).
PhD thesis grant

FONDO NACIONAL DE CIENCIA,TECNOLOGIA E INNOVACION

Chile, 2001

National Foundation of Science and Technology (FONDECYT, Chile) merit funding 2001-2003 Award for best Ph.D thesis by Chilean Government (2001).


The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Stanic, Karen; Reig, German; Wichmann, Ignacio A; Opazo, Juan C; Owen, Gareth I; Corvalán, Alejandro H; Concha, Miguel L; Amigo, Julio D Article Scientific reports (2019)
Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio) Stanic K.; Quiroz, A; Lemus, CG; Wichmann, IA; Corvalan, AH; Owen, GI; Opazo, JC; Concha, ML; Amigo, JD Article ISI SCOPUS Frontiers in Neuroanatomy (2018)
Reprimo tissue-specific expression pattern is conserved between zebrafish and human. Figueroa, Ricardo J; Carrasco-Avino, Gonzalo; Wichmann, Ignacio A; Lange, Martin; Owen, Gareth I; Siekmann, Arndt F; Corvalán, Alejandro H; Opazo, Juan C; Amigo, Julio D Article PloS one (2017)
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage. Wichmann, Ignacio A; Zavala, Kattina; Hoffmann, Federico G; Vandewege, Michael W; Corvalán, Alejandro H; Amigo, Julio D; Owen, Gareth I; Opazo, Juan C Article Gene (2016)
Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis Amigo, JD; Yu M.; Troadec, MB; Gwynn, B; Cooney, JD; Lambert, AJ; Chi, NC; Weiss, MJ; Peters, LL; Kaplan J.; Cantor, AB; Paw, BH Article ISI MOLECULAR AND CELLULAR BIOLOGY (2011)
miR-451 protects against erythroid oxidant stress by repressing 14-3-3 zeta Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ. Article ISI GENES DEVELOPMENT (2010)
A GATA-1-regulated microRNA locus essential for erythropoiesis. Dore LC, Amigo JD, Dos Santos CO, Zhang Z, Gai X, Tobias JW, Yu D, Klein AM, Dorman C, Wu W, Hardison RC, Paw BH, Weiss MJ. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M, Hamza I. Article NATURE (2008)
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease Alvarez, AR; Klein, A.; Castro J.; Cancino, GI; Amigo, J; Mosqueira, M; Vargas LM; Yevenes, LF; Bronfman, FC; Zanlungo S. Article ISI SCOPUS FASEB JOURNAL (2008)
Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Shmukler BE, Clark JS, Hsu A, Vandorpe DH, Stewart AK, Kurschat CE, Choe SK, Zhou Y, Amigo J, Paw BH, Alper SL. Article Am J Physiol Regul Integr Comp Physiol. (2008)
Gateway compatible vectors for analysis of gene function in the zebrafish. Villefranc JA1, Amigo J, Lawson ND. Article Dev. Dyn (2007)
pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Buchner DA, Su F, Yamaoka JS, Kamei M, Shavit JA, Barthel LK, McGee B, Amigo JD, Kim S, Hanosh AW, Jagadeeswaran P, Goldman D, Lawson ND, Raymond PA, Weinstein BM, Ginsburg D, Lyons SE. Article Proceedings of the National Academy of Sciences (2007)
Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Covassin L, Amigo JD, Suzuki K, Teplyuk V, Straubhaar J, Lawson ND. Article Dev Biol. (2006)
Acute activation of Maxi-K channels (hSlo) by estradiol binding to the ? subunit Valverde M.A.; Rojas P.; Amigo, J; Cosmelli, D; Orio, P; Bahamonde M.I.; Vergara C.; Latorre R.; Mann G.E. Article SCIENCE (1999)
Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit Valverde, MA; Rojas, P; Amigo, J; Cosmelli, D; Orio, P; Bahamonde, MI; Mann, GE; Vergara, C; Latorre, R Article ISI SCIENCE (1999)
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel Diaz L.; Amigo, J; Alvarez, O; Latorre R.; Stefani E.; Meera, P; Toro, L. Article JOURNAL OF BIOLOGICAL CHEMISTRY (1998)
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Julio D Amigo, Ming Yu, Marie-Berengere Troadec, Babette Gwynn, Jeffrey D Cooney, Amy J Lambert, Neil C Chi, Mitchell J Weiss, Luanne L Peters, Jerry Kaplan, Alan B Cantor, Barry H Paw Article MOLECULAR AND CELLULAR BIOLOGY
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Amigo, JD Article GENES DEVELOPMENT
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Amigo, JD Article BLOOD


molecular-functional dissection of pericyte contribution to sprouting angiogenesis in zebrafish ICGEB (ICGEB CH15-01) Proyecto 2017-2019 Inv. Principal
Visualization and Manipulation of Signals and Forces in Developing Tissues PIA (ACT1402) Proyecto 2016-2019 Inv. Principal
High-Throughput In Vivo Zebrafish Screening Platform MIT (MISTI/MIT) Proyecto 2015-2017 Inv. Principal
BMBF PCI (20140027) Proyecto 2014-2018 Inv. Principal


The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties Amigo, JD; Opazo, JC; Jorquera, R; Wichmann, IA; Garcia-Bloj, BA; Alarcon, MA; Owen, GI; Corvalan, AH Review ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)