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Patricia Macanas Pirard

Profesor Asistente Adjunto

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

Tumor microenvironment; Drug resistance mechanism in tumor cells; Drug Interaction, Hematopoietic Cell Transplantation; Acute Myeloid Leukemia; Bone Marrow Microenvironment; Hox genes and cancer, Multi-drug resistance and apoptosis in cancer.

Medical Biochemistry, University of Surrey. Reino Unido, 2000
Molecular Toxicology, University of Surrey. Reino Unido, 2004

Instructor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2008 - 2017
Profesor Asistente Adjunto Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2017 - A la fecha

Research Fellow Full Time

Postgraduate Medical School

Guildford, Reino Unido

2004 - 2007
Instructor Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2008 - 2017
Profesor Asistente Adjunto Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2017 - A la fecha


Metformin protects from oxaliplatin induced peripheral neuropathy in rats Martinez, NW; Sanchez, A; Diaz, P; Broekhuizen, R.; Godoy, J.; Mondaca S.; Catenaccio, A; Macanas, P.; Nervi, B.; Calvo, M; Court, FA Article Neurobiol Pain (2020)
Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome Macanas-Pirard, Patricia; Broekhuizen, Richard; González, Alfonso; Oyanadel, Claudia; Ernst, Daniel; García, Patricia; Montecinos, Viviana P.; Court, Felipe; Ocqueteau, Mauricio; Ramirez, Pablo; Nervi, Bruno Article ISI SCOPUS ONCOTARGET (2017)
The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells Macanas-Pirard, Patricia; Quezada, Thomas; Navarrete, Leonardo; Broekhuizen, Richard; Leisewitz, Andrea; Nervi, Bruno; Ramírez, Pablo A.; Proost, Paul Article ISI SCOPUS PLOS ONE (2017)
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients Espinoza, J.A; Garcia P.; Bizama, C; Leal J.L.; Riquelme I.; Weber, H; Macanas, P.; Aguayo, G; Viñuela E.; Roa, J.C; Nervi, B Article ISI SCOPUS Histopathology (2016)
Bone Marrow Stromal Cells Modulate Mouse ENT1 Activity and Protect Leukemia Cells from Cytarabine Induced Apoptosis Macanas Pirard, P; Leisewitz, A.; Broekhuizen, R.; Cautivo, K.; Barriga F.M.; Leisewitz, F; Gidi, V; Riquelme E.; Montecinos, V. P.; Swett P.; Besa P.; Ramirez, P; Ocqueteau, M; Kalergis, A.M.; Holt M.; Rettig M.; DiPersio J.F.; Nervi, B Article ISI SCOPUS PLOS ONE (2012)
Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. Macanas-Pirard, Patricia; Leisewitz, Andrea; Broekhuizen, Richard; Cautivo, Kelly; Barriga, Francisco M; Leisewitz, Francisco; Gidi, Victoria; Riquelme, Erick; Montecinos, Viviana P; Swett, Pilar; Besa, Pelayo; Ramirez, Pablo; Ocqueteau, Mauricio; Kalergis, Alexis M; Holt, Matthew; Rettig, Michael; DiPersio, John F; Nervi, Bruno Article PloS one (2012)
A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer. Sooriakumaran, P; Macanas-Pirard, P; Bucca, G; Henderson, A; Langley, S E M; Laing, R W; Smith, C P; Laing, E E; Coley, H M Article Cancer genomics & proteomics (2009)
A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. Sooriakumaran, Prasanna; Coley, Helen M; Fox, Stephen B; Macanas-Pirard, Patricia; Lovell, David P; Henderson, Alastair; Eden, Chris G; Miller, Paul D; Langley, Stephen E M; Laing, Robert W Article Anticancer research (2009)
The effects of cyclooxygenase-2 expression in prostate cancer cells: modulation of response to cytotoxic agents. Mehar, Ayaz; Macanas-Pirard, Patricia; Mizokami, Atsushi; Takahashi, Yutaka; Kass, Georges E N; Coley, Helen M Article The Journal of pharmacology and experimental therapeutics (2008)
Antagonism of HOX/PBX Dimer Formation Blocks the In vivo Proliferation of Melanoma Morgan, R.; Pirard, P. M.; Shears, L.; Sohal, J.; Pettengell, R.; Pandha, H. S. Article CANCER RESEARCH (2007)
Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells Macanas-Pirard, P. Article Journal of Pharmacology and Experimental Therapeutics (2005)
Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells. Macanas-Pirard, Patricia; Yaacob, Nik-Soriani; Lee, Pauline C; Holder, Julie C; Hinton, Richard H; Kass, George E N Article The Journal of pharmacology and experimental therapeutics (2005)
Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases. El-Hassan, Hasan; Anwar, Khurshid; Macanas-Pirard, Patricia; Crabtree, Mark; Chow, Sek C; Johnson, Victoria L; Lee, Pauline C; Hinton, Richard H; Price, Shirley C; Kass, George E N Article Toxicology and applied pharmacology (2003)
The role of apoptosis in acetaminophen-induced injury. Kass, George E N; Macanas-Pirard, Patricia; Lee, Pauline C; Hinton, Richard H Article Annals of the New York Academy of Sciences (2003)


MÉTODO EX VIVO PRONOSTICO Y PREDICTIVO DE RESPUESTA DE UN CÁNCER AL TRATAMIENTO CON UN AGENTE ANTITUMORAL. Macanas Pirard, P; Nervi, Bruno; Broekhuizen, Richard Patent (2019)


“Desarrollo de un test multigénico para pronóstico de LMA interrogando al estroma tumoral” Nervi, Bruno; Macanas-Pirard, Patricia Proyecto Proyecto Fondef IT20I0100 (2021)
The modulation of the leukemia-stroma interaction as a new strategy to improve outcomes in acute myeloid leukemia Nervi, Bruno; Macanas-Pirard, Patricia Proyecto Proyecto Fondecyt Regular #1181792 (2018)
Desarrollo de un test pronostico para LMA interrogando por primera vez al estroma tumoral Nervi, Bruno; Macanas-Pirard, Patricia Proyecto III Proyecto Fondef IDeA en 2 etapas, comenzó el proyecto el 2/01/2017 (2017)
Desarrollo de un test predictivo de respuesta para LMA basado en la resistencia a quimioterapia conferida por el estroma tumoral de la médula osea Nervi, Bruno; Macanas-Pirard, Patricia Proyecto Proyecto Nacional CORFO 15IPPID-45692 (2015)
Preferential mobilization of leukemia precursors from the bone marrow into peripheral blood by the CXCR4 inhibitor AMD3100 in a mouse model Nervi, Bruno; Macanas-Pirard, Patricia Proyecto Proyecto Internacional con la empresa farmacéutica Genzyme (2009)
THE INTERACTION BETWEEN LEUKEMIA AND BONE MARROW STROMA PROTECTS THE TUMOR CELLS FROM DRUG INDUCED APOPTOSIS Nervi, Bruno; Macanas-Pirard, Patricia Proyecto Proyecto Fondecyt Iniciacion #11085015 (2008)