Gallbladder Cancer in Chile Pathologic Characteristics of Survival and Prognostic Factors: Analysis of 1,366 Cases

Roa, I; Ibacache, G; Munoz S.; De Aretxabala X.

Abstract

Objectives: To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile. Methods: Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC. Results: Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.6%) cases of mucosal carcinoma, 132 (9.7%) cases of muscular carcinoma, 316 (23.1%) cases of subserosal carcinoma, 382 (28.0%) cases of serosal carcinoma, and 323 (23.6%) cases beyond the serosa. Women older than 55 years with a gallbladder length greater than 9.5 cm had a five-times-greater relative risk of cancer. Those with a gallbladder wall thickness less than 7 mm had a better 5-year survival rate than those with a gallbladder wall thickness greater than 10 mm (P = .0001). Patients who had cholesterolosis of the gallbladder had 9.2 times less probability of having cancer. The infiltration level of the gallbladder wall was the most important independent prognostic factor (P < .001), followed by differentiation and lymphatic involvement (P < .001 and P = .05, respectively). Vascular infiltration had a mortality rate of 100%. Conclusions: Morphologic features are strongly associated with the prognosis of GBC and must be taken into consideration when supplementary treatment is recommended.

Más información

Título según WOS: Gallbladder Cancer in Chile Pathologic Characteristics of Survival and Prognostic Factors: Analysis of 1,366 Cases
Título según SCOPUS: Gallbladder cancer in Chile: Pathologic characteristics of survival and prognostic factors: Analysis of 1,366 cases
Título de la Revista: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volumen: 141
Número: 5
Editorial: OXFORD UNIV PRESS INC
Fecha de publicación: 2014
Página de inicio: 675
Página final: 682
Idioma: English
DOI:

10.1309/AJCPQT3ELN2BBCKA

Notas: ISI, SCOPUS